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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDMCP All Species: 24.85
Human Site: T195 Identified Species: 45.56
UniProt: Q6Q0C1 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6Q0C1 NP_997000.2 308 33435 T195 R D G H S F A T Y F L S Y A V
Chimpanzee Pan troglodytes XP_001159368 308 33445 T195 R D G H S F A T Y F L S Y A V
Rhesus Macaque Macaca mulatta XP_001113849 288 31847 I180 R D T P T M G I Y F I T Y E G
Dog Lupus familis XP_855336 388 41936 T265 R D G H S F A T Y F L S Y T I
Cat Felis silvestris
Mouse Mus musculus Q6IS41 310 33627 T197 R E G H S F A T Y F L S Y A M
Rat Rattus norvegicus Q6J329 310 33599 T197 R E G H S F A T Y F L S Y A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512948 482 52245 T369 R D C H S F A T Y F L S Y S I
Chicken Gallus gallus XP_421367 330 35816 K232 D W L T P A G K N K P G F L V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A4QNX2 288 31518 N196 C E I L T T E N Q R P G W P V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VQG4 306 32934 L191 R D L P A N G L Y F L V Y E A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q27257 312 33116 A182 R D I P A S A A Y L S V Y E Y
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q93XM7 300 31004 A197 T M F A A Y E A F K R F L A G
Baker's Yeast Sacchar. cerevisiae P32331 307 33357 T193 R E G H G C G T Y F L V Y E A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.7 43.1 68.5 N.A. 87.7 86.4 N.A. 37.7 54.8 N.A. 52.9 N.A. 20.4 N.A. 33.3 N.A.
Protein Similarity: 100 98.3 62 71.6 N.A. 91.2 90.6 N.A. 47.2 68.1 N.A. 66.2 N.A. 35.3 N.A. 48 N.A.
P-Site Identity: 100 100 33.3 86.6 N.A. 86.6 93.3 N.A. 80 6.6 N.A. 6.6 N.A. 40 N.A. 33.3 N.A.
P-Site Similarity: 100 100 53.3 93.3 N.A. 100 100 N.A. 93.3 13.3 N.A. 26.6 N.A. 46.6 N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 33.7 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. 47.7 38.6 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 24 8 54 16 0 0 0 0 0 39 16 % A
% Cys: 8 0 8 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 54 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 31 0 0 0 0 16 0 0 0 0 0 0 31 0 % E
% Phe: 0 0 8 0 0 47 0 0 8 70 0 8 8 0 0 % F
% Gly: 0 0 47 0 8 0 31 0 0 0 0 16 0 0 16 % G
% His: 0 0 0 54 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 16 0 0 0 0 8 0 0 8 0 0 0 16 % I
% Lys: 0 0 0 0 0 0 0 8 0 16 0 0 0 0 0 % K
% Leu: 0 0 16 8 0 0 0 8 0 8 62 0 8 8 0 % L
% Met: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 0 8 0 8 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 24 8 0 0 0 0 0 16 0 0 8 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 77 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % R
% Ser: 0 0 0 0 47 8 0 0 0 0 8 47 0 8 0 % S
% Thr: 8 0 8 8 16 8 0 54 0 0 0 8 0 8 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 24 0 0 39 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 77 0 0 0 77 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _