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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SHC4
All Species:
13.33
Human Site:
Y375
Identified Species:
36.67
UniProt:
Q6S5L8
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6S5L8
NP_976224.3
630
68785
Y375
E
R
E
D
H
E
Y
Y
N
E
I
P
G
K
Q
Chimpanzee
Pan troglodytes
XP_510385
630
68837
Y375
E
R
E
D
H
E
Y
Y
N
E
I
P
G
K
Q
Rhesus Macaque
Macaca mulatta
XP_001113330
630
68700
Y375
E
S
E
D
H
E
Y
Y
N
E
I
P
G
K
Q
Dog
Lupus familis
XP_544671
632
68540
Y377
E
R
E
D
H
E
Y
Y
N
E
I
P
G
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q6S5L9
626
68500
D371
A
P
E
D
R
D
H
D
Y
Y
N
S
I
P
G
Rat
Rattus norvegicus
O70143
594
64082
P346
H
P
Y
Y
N
S
V
P
N
K
M
P
P
P
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_424123
437
47989
E190
Y
N
E
I
P
G
K
E
P
P
A
G
G
V
L
Frog
Xenopus laevis
Q8AY68
465
51711
A218
V
T
P
H
D
R
M
A
G
F
D
G
S
A
W
Zebra Danio
Brachydanio rerio
XP_001921625
593
63809
K346
Q
A
F
E
L
R
F
K
Q
Y
L
K
N
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.4
88.6
N.A.
79.8
42.5
N.A.
N.A.
51.1
42.3
43.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98
92.4
N.A.
86.6
57.2
N.A.
N.A.
57.4
51.9
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
100
N.A.
13.3
13.3
N.A.
N.A.
13.3
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
26.6
33.3
N.A.
N.A.
13.3
0
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
12
0
0
0
0
0
12
0
0
12
0
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
56
12
12
0
12
0
0
12
0
0
0
0
% D
% Glu:
45
0
67
12
0
45
0
12
0
45
0
0
0
0
0
% E
% Phe:
0
0
12
0
0
0
12
0
0
12
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
12
0
0
12
0
0
23
56
0
23
% G
% His:
12
0
0
12
45
0
12
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
12
0
0
0
0
0
0
45
0
12
0
0
% I
% Lys:
0
0
0
0
0
0
12
12
0
12
0
12
0
45
0
% K
% Leu:
0
0
0
0
12
0
0
0
0
0
12
0
0
0
12
% L
% Met:
0
0
0
0
0
0
12
0
0
0
12
0
0
0
0
% M
% Asn:
0
12
0
0
12
0
0
0
56
0
12
0
12
0
0
% N
% Pro:
0
23
12
0
12
0
0
12
12
12
0
56
12
34
12
% P
% Gln:
12
0
0
0
0
0
0
0
12
0
0
0
0
0
45
% Q
% Arg:
0
34
0
0
12
23
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
12
0
0
0
12
0
0
0
0
0
12
12
0
0
% S
% Thr:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
12
0
0
0
0
0
12
0
0
0
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% W
% Tyr:
12
0
12
12
0
0
45
45
12
23
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _