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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1L
All Species:
19.7
Human Site:
S297
Identified Species:
33.33
UniProt:
Q6UB35
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UB35
NP_056255.2
978
105790
S297
N
C
S
H
D
F
L
S
G
K
V
G
C
G
S
Chimpanzee
Pan troglodytes
XP_518807
1117
120378
S436
N
C
S
H
D
F
L
S
G
K
V
G
C
G
S
Rhesus Macaque
Macaca mulatta
XP_001098522
975
105686
S294
N
C
S
H
D
F
L
S
G
K
V
G
C
G
S
Dog
Lupus familis
XP_533450
923
99956
S242
N
C
S
H
D
F
L
S
G
K
L
G
C
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3V3R1
977
105710
S296
N
C
F
H
D
F
L
S
G
K
L
S
G
G
S
Rat
Rattus norvegicus
P27653
935
100977
P242
D
C
G
I
N
Y
V
P
D
D
T
K
P
N
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419672
1009
108963
S326
N
C
S
P
D
L
L
S
G
R
Q
S
L
N
C
Frog
Xenopus laevis
NP_001080574
934
100531
A256
K
R
V
V
G
D
V
A
Y
V
E
A
K
E
K
Zebra Danio
Brachydanio rerio
XP_697909
969
105090
E300
N
L
G
S
A
L
L
E
V
E
A
Q
S
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
P275
D
C
G
I
N
V
K
P
D
A
S
K
A
S
G
Honey Bee
Apis mellifera
XP_623070
937
101449
P244
D
C
G
I
N
S
I
P
D
S
T
K
N
N
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001184686
696
75269
L73
M
R
Y
L
P
L
H
L
K
Q
P
V
P
T
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
V11
S
T
R
K
L
E
V
V
S
P
V
P
A
D
I
Baker's Yeast
Sacchar. cerevisiae
P09440
975
106199
P271
D
V
G
I
N
Y
V
P
D
I
S
K
K
S
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.2
97.4
87.5
N.A.
88.3
57.2
N.A.
N.A.
70.8
57.4
65.2
N.A.
50.9
49.2
N.A.
50.5
Protein Similarity:
100
87.4
98
91
N.A.
91.8
71.8
N.A.
N.A.
82.2
71.8
77
N.A.
66.2
66
N.A.
59.8
P-Site Identity:
100
100
100
93.3
N.A.
73.3
6.6
N.A.
N.A.
46.6
0
13.3
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
80
33.3
N.A.
N.A.
53.3
13.3
26.6
N.A.
20
26.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
48
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
8
0
8
8
8
15
8
8
% A
% Cys:
0
65
0
0
0
0
0
0
0
0
0
0
29
0
8
% C
% Asp:
29
0
0
0
43
8
0
0
29
8
0
0
0
8
8
% D
% Glu:
0
0
0
0
0
8
0
8
0
8
8
0
0
8
0
% E
% Phe:
0
0
8
0
0
36
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
36
0
8
0
0
0
43
0
0
29
8
36
29
% G
% His:
0
0
0
36
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
29
0
0
8
0
0
8
0
0
0
0
8
% I
% Lys:
8
0
0
8
0
0
8
0
8
36
0
29
15
0
8
% K
% Leu:
0
8
0
8
8
22
50
8
0
0
15
0
8
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
50
0
0
0
29
0
0
0
0
0
0
0
8
22
0
% N
% Pro:
0
0
0
8
8
0
0
29
0
8
8
8
15
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% Q
% Arg:
0
15
8
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
8
0
36
8
0
8
0
43
8
8
15
15
8
15
36
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
15
0
0
8
0
% T
% Val:
0
8
8
8
0
8
29
8
8
8
29
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
15
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _