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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1L
All Species:
33.03
Human Site:
S357
Identified Species:
55.9
UniProt:
Q6UB35
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UB35
NP_056255.2
978
105790
S357
C
L
K
L
Q
P
L
S
P
V
P
S
D
I
E
Chimpanzee
Pan troglodytes
XP_518807
1117
120378
S496
C
L
K
L
Q
P
L
S
P
V
P
S
D
I
E
Rhesus Macaque
Macaca mulatta
XP_001098522
975
105686
S354
C
L
K
L
Q
P
L
S
P
V
P
S
D
I
E
Dog
Lupus familis
XP_533450
923
99956
S302
C
L
K
L
Q
P
L
S
P
V
P
S
D
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q3V3R1
977
105710
S356
C
L
K
L
Q
P
L
S
P
V
P
S
D
I
E
Rat
Rattus norvegicus
P27653
935
100977
T314
Y
N
K
L
N
L
K
T
P
V
P
S
D
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419672
1009
108963
S388
C
L
K
L
Q
P
L
S
P
V
P
S
D
I
E
Frog
Xenopus laevis
NP_001080574
934
100531
V313
Y
N
K
L
H
L
K
V
P
V
P
S
D
I
E
Zebra Danio
Brachydanio rerio
XP_697909
969
105090
S348
P
L
K
L
H
P
L
S
P
V
P
S
D
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
R347
T
L
P
L
K
P
Q
R
P
V
P
S
D
I
V
Honey Bee
Apis mellifera
XP_623070
937
101449
K316
I
L
K
I
N
P
Q
K
P
V
P
S
D
I
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001184686
696
75269
K111
S
E
I
D
Y
Y
G
K
T
K
A
K
I
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
Y49
H
Y
D
L
Y
G
K
Y
K
A
K
V
L
L
S
Baker's Yeast
Sacchar. cerevisiae
P09440
975
106199
S342
P
L
P
L
H
L
E
S
P
V
P
S
D
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.2
97.4
87.5
N.A.
88.3
57.2
N.A.
N.A.
70.8
57.4
65.2
N.A.
50.9
49.2
N.A.
50.5
Protein Similarity:
100
87.4
98
91
N.A.
91.8
71.8
N.A.
N.A.
82.2
71.8
77
N.A.
66.2
66
N.A.
59.8
P-Site Identity:
100
100
100
93.3
N.A.
100
53.3
N.A.
N.A.
100
60
86.6
N.A.
60
60
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
60
N.A.
N.A.
100
60
86.6
N.A.
66.6
66.6
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
48
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
8
% A
% Cys:
43
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
0
0
0
0
0
86
0
8
% D
% Glu:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
58
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% G
% His:
8
0
0
0
22
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
8
0
0
0
0
0
0
0
0
8
79
0
% I
% Lys:
0
0
72
0
8
0
22
15
8
8
8
8
0
0
0
% K
% Leu:
0
72
0
86
0
22
50
0
0
0
0
0
8
15
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
0
0
15
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
15
0
15
0
0
65
0
0
86
0
86
0
0
0
0
% P
% Gln:
0
0
0
0
43
0
15
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
0
0
58
0
0
0
86
0
8
8
% S
% Thr:
8
0
0
0
0
0
0
8
8
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
8
0
86
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
15
8
0
0
15
8
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _