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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1L
All Species:
44.55
Human Site:
S456
Identified Species:
75.38
UniProt:
Q6UB35
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UB35
NP_056255.2
978
105790
S456
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Chimpanzee
Pan troglodytes
XP_518807
1117
120378
S595
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Rhesus Macaque
Macaca mulatta
XP_001098522
975
105686
S453
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Dog
Lupus familis
XP_533450
923
99956
S401
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Cat
Felis silvestris
Mouse
Mus musculus
Q3V3R1
977
105710
S455
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Rat
Rattus norvegicus
P27653
935
100977
S413
F
A
C
V
R
Q
P
S
Q
G
P
T
F
G
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419672
1009
108963
S487
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Frog
Xenopus laevis
NP_001080574
934
100531
S412
F
A
C
V
R
Q
P
S
Q
G
P
T
F
G
I
Zebra Danio
Brachydanio rerio
XP_697909
969
105090
S447
F
A
C
L
R
Q
P
S
Q
G
P
T
F
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
S446
M
A
A
L
R
Q
P
S
Q
G
P
T
F
G
I
Honey Bee
Apis mellifera
XP_623070
937
101449
S415
F
V
T
L
R
Q
P
S
Q
G
P
T
F
G
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001184686
696
75269
T204
E
E
F
N
L
H
L
T
G
D
I
H
A
I
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
G142
E
F
N
L
H
L
T
G
D
I
H
A
I
T
A
Baker's Yeast
Sacchar. cerevisiae
P09440
975
106199
L442
A
N
V
R
Q
P
S
L
G
P
T
L
G
V
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.2
97.4
87.5
N.A.
88.3
57.2
N.A.
N.A.
70.8
57.4
65.2
N.A.
50.9
49.2
N.A.
50.5
Protein Similarity:
100
87.4
98
91
N.A.
91.8
71.8
N.A.
N.A.
82.2
71.8
77
N.A.
66.2
66
N.A.
59.8
P-Site Identity:
100
100
100
100
N.A.
100
86.6
N.A.
N.A.
100
86.6
100
N.A.
80
86.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
86.6
86.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
48
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
72
8
0
0
0
0
0
0
0
0
8
8
0
8
% A
% Cys:
0
0
65
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% D
% Glu:
15
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
72
8
8
0
0
0
0
0
0
0
0
0
79
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
15
79
0
0
8
79
0
% G
% His:
0
0
0
0
8
8
0
0
0
0
8
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
8
0
8
8
22
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% K
% Leu:
0
0
0
72
8
8
8
8
0
0
0
8
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
79
0
0
8
79
0
0
0
0
% P
% Gln:
0
0
0
0
8
79
0
0
79
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
79
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
8
79
0
0
0
0
0
0
0
% S
% Thr:
0
0
8
0
0
0
8
8
0
0
8
79
0
8
8
% T
% Val:
0
8
8
15
0
0
0
0
0
0
0
0
0
8
58
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _