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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD1L All Species: 14.55
Human Site: S73 Identified Species: 24.62
UniProt: Q6UB35 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6UB35 NP_056255.2 978 105790 S73 R T P A A R D S I V R E V I Q
Chimpanzee Pan troglodytes XP_518807 1117 120378 S212 R T P A A R D S I V R E V I Q
Rhesus Macaque Macaca mulatta XP_001098522 975 105686 S70 R T P A A R D S I V R E V I Q
Dog Lupus familis XP_533450 923 99956 I48 F K P V L A I I Q A G D D N L
Cat Felis silvestris
Mouse Mus musculus Q3V3R1 977 105710 S72 P E A P G M D S I V R D V I H
Rat Rattus norvegicus P27653 935 100977 D48 L Q V G D R D D S N L Y I N V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419672 1009 108963 A131 L E F K R A S A F S H I V E A
Frog Xenopus laevis NP_001080574 934 100531 Y51 D R D D S N L Y I S M K L K A
Zebra Danio Brachydanio rerio XP_697909 969 105090 R76 Y E G P P Y E R A V G D I V Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96553 968 103485 P70 K Q L A D F V P G L R I V Q V
Honey Bee Apis mellifera XP_623070 937 101449 G48 L A I V Q V G G R E D S N V Y
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001184686 696 75269
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPK5 634 67783
Baker's Yeast Sacchar. cerevisiae P09440 975 106199 T68 K H P N F K P T L K I I Q V G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.2 97.4 87.5 N.A. 88.3 57.2 N.A. N.A. 70.8 57.4 65.2 N.A. 50.9 49.2 N.A. 50.5
Protein Similarity: 100 87.4 98 91 N.A. 91.8 71.8 N.A. N.A. 82.2 71.8 77 N.A. 66.2 66 N.A. 59.8
P-Site Identity: 100 100 100 6.6 N.A. 46.6 13.3 N.A. N.A. 6.6 6.6 13.3 N.A. 20 0 N.A. 0
P-Site Similarity: 100 100 100 13.3 N.A. 53.3 20 N.A. N.A. 13.3 26.6 40 N.A. 33.3 6.6 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 44.6 48 N.A.
Protein Similarity: N.A. N.A. N.A. 51.9 64.1 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 29 22 15 0 8 8 8 0 0 0 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 8 8 15 0 36 8 0 0 8 22 8 0 0 % D
% Glu: 0 22 0 0 0 0 8 0 0 8 0 22 0 8 0 % E
% Phe: 8 0 8 0 8 8 0 0 8 0 0 0 0 0 0 % F
% Gly: 0 0 8 8 8 0 8 8 8 0 15 0 0 0 8 % G
% His: 0 8 0 0 0 0 0 0 0 0 8 0 0 0 8 % H
% Ile: 0 0 8 0 0 0 8 8 36 0 8 22 15 29 0 % I
% Lys: 15 8 0 8 0 8 0 0 0 8 0 8 0 8 0 % K
% Leu: 22 0 8 0 8 0 8 0 8 8 8 0 8 0 8 % L
% Met: 0 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 8 0 8 0 0 0 8 0 0 8 15 0 % N
% Pro: 8 0 36 15 8 0 8 8 0 0 0 0 0 0 0 % P
% Gln: 0 15 0 0 8 0 0 0 8 0 0 0 8 8 29 % Q
% Arg: 22 8 0 0 8 29 0 8 8 0 36 0 0 0 0 % R
% Ser: 0 0 0 0 8 0 8 29 8 15 0 8 0 0 0 % S
% Thr: 0 22 0 0 0 0 0 8 0 0 0 0 0 0 0 % T
% Val: 0 0 8 15 0 8 8 0 0 36 0 0 43 22 15 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 8 0 8 0 0 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _