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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1L
All Species:
38.48
Human Site:
T514
Identified Species:
65.13
UniProt:
Q6UB35
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UB35
NP_056255.2
978
105790
T514
I
L
H
E
N
T
Q
T
D
K
A
L
Y
N
R
Chimpanzee
Pan troglodytes
XP_518807
1117
120378
T653
I
L
H
E
N
T
Q
T
D
K
A
L
Y
N
R
Rhesus Macaque
Macaca mulatta
XP_001098522
975
105686
T511
I
L
H
E
N
T
Q
T
D
K
A
L
Y
N
R
Dog
Lupus familis
XP_533450
923
99956
T459
I
L
H
E
N
T
Q
T
D
K
A
L
Y
N
R
Cat
Felis silvestris
Mouse
Mus musculus
Q3V3R1
977
105710
T513
I
L
H
E
S
T
Q
T
D
K
A
L
Y
N
R
Rat
Rattus norvegicus
P27653
935
100977
T471
I
F
H
E
L
T
Q
T
D
K
A
L
F
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419672
1009
108963
S545
I
L
H
E
S
T
Q
S
D
K
A
L
Y
N
R
Frog
Xenopus laevis
NP_001080574
934
100531
S470
I
F
H
E
L
T
Q
S
D
K
A
L
Y
S
R
Zebra Danio
Brachydanio rerio
XP_697909
969
105090
S505
I
L
H
E
A
T
Q
S
D
K
A
L
Y
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
K504
I
F
H
E
N
T
Q
K
D
K
A
L
Y
D
R
Honey Bee
Apis mellifera
XP_623070
937
101449
T473
Y
F
H
E
C
T
Q
T
D
E
A
L
Y
N
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001184686
696
75269
G262
I
G
R
L
Q
R
L
G
I
D
K
T
N
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
G200
F
R
R
L
T
K
L
G
I
S
K
T
S
P
E
Baker's Yeast
Sacchar. cerevisiae
P09440
975
106199
N500
F
H
E
A
T
Q
K
N
D
S
T
F
Y
K
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.2
97.4
87.5
N.A.
88.3
57.2
N.A.
N.A.
70.8
57.4
65.2
N.A.
50.9
49.2
N.A.
50.5
Protein Similarity:
100
87.4
98
91
N.A.
91.8
71.8
N.A.
N.A.
82.2
71.8
77
N.A.
66.2
66
N.A.
59.8
P-Site Identity:
100
100
100
100
N.A.
93.3
80
N.A.
N.A.
86.6
73.3
80
N.A.
80
73.3
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
86.6
N.A.
N.A.
100
86.6
93.3
N.A.
86.6
80
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
48
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
0
0
0
79
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
86
8
0
0
0
8
8
% D
% Glu:
0
0
8
79
0
0
0
0
0
8
0
0
0
0
8
% E
% Phe:
15
29
0
0
0
0
0
0
0
0
0
8
8
0
0
% F
% Gly:
0
8
0
0
0
0
0
15
0
0
0
0
0
0
0
% G
% His:
0
8
79
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
79
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
8
8
8
0
72
15
0
0
8
0
% K
% Leu:
0
50
0
15
15
0
15
0
0
0
0
79
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
36
0
0
8
0
0
0
0
8
58
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% P
% Gln:
0
0
0
0
8
8
79
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
15
0
0
8
0
0
0
0
0
0
0
0
86
% R
% Ser:
0
0
0
0
15
0
0
22
0
15
0
0
8
15
0
% S
% Thr:
0
0
0
0
15
79
0
50
0
0
8
15
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
79
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _