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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1L
All Species:
44.85
Human Site:
T588
Identified Species:
75.9
UniProt:
Q6UB35
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UB35
NP_056255.2
978
105790
T588
D
R
F
L
R
K
I
T
I
G
Q
G
N
T
E
Chimpanzee
Pan troglodytes
XP_518807
1117
120378
T727
D
R
F
L
R
K
I
T
I
G
Q
G
N
A
E
Rhesus Macaque
Macaca mulatta
XP_001098522
975
105686
T585
D
R
F
L
R
K
I
T
I
G
Q
G
N
T
E
Dog
Lupus familis
XP_533450
923
99956
T533
D
R
F
L
R
K
M
T
I
G
Q
A
P
T
E
Cat
Felis silvestris
Mouse
Mus musculus
Q3V3R1
977
105710
T587
D
R
F
L
R
K
I
T
I
G
Q
G
S
T
E
Rat
Rattus norvegicus
P27653
935
100977
T545
D
R
F
L
R
K
I
T
I
G
Q
A
P
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419672
1009
108963
T619
D
R
F
L
R
K
I
T
V
G
Q
A
N
T
E
Frog
Xenopus laevis
NP_001080574
934
100531
T544
D
R
F
L
R
K
I
T
I
G
Q
A
P
T
E
Zebra Danio
Brachydanio rerio
XP_697909
969
105090
T579
D
R
F
L
R
K
I
T
I
G
Q
A
N
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
T578
D
R
Y
L
R
T
I
T
V
G
Q
S
P
T
E
Honey Bee
Apis mellifera
XP_623070
937
101449
T547
D
R
F
L
R
K
I
T
I
G
E
N
P
T
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001184686
696
75269
L336
E
I
M
A
I
L
A
L
T
T
D
L
K
D
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
L274
E
I
M
A
V
L
A
L
T
T
S
L
G
D
M
Baker's Yeast
Sacchar. cerevisiae
P09440
975
106199
T574
D
R
M
L
R
Q
I
T
I
G
E
A
A
T
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.2
97.4
87.5
N.A.
88.3
57.2
N.A.
N.A.
70.8
57.4
65.2
N.A.
50.9
49.2
N.A.
50.5
Protein Similarity:
100
87.4
98
91
N.A.
91.8
71.8
N.A.
N.A.
82.2
71.8
77
N.A.
66.2
66
N.A.
59.8
P-Site Identity:
100
93.3
100
80
N.A.
93.3
86.6
N.A.
N.A.
86.6
86.6
93.3
N.A.
66.6
80
N.A.
0
P-Site Similarity:
100
93.3
100
86.6
N.A.
100
86.6
N.A.
N.A.
93.3
86.6
93.3
N.A.
80
86.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
48
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
0
0
15
0
0
0
0
43
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
86
0
0
0
0
0
0
0
0
0
8
0
0
15
0
% D
% Glu:
15
0
0
0
0
0
0
0
0
0
15
0
0
0
86
% E
% Phe:
0
0
72
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
86
0
29
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
15
0
0
8
0
79
0
72
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
72
0
0
0
0
0
0
8
0
0
% K
% Leu:
0
0
0
86
0
15
0
15
0
0
0
15
0
0
0
% L
% Met:
0
0
22
0
0
0
8
0
0
0
0
0
0
0
15
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
8
36
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
36
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
72
0
0
0
0
% Q
% Arg:
0
86
0
0
86
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
8
8
8
0
0
% S
% Thr:
0
0
0
0
0
8
0
86
15
15
0
0
0
79
0
% T
% Val:
0
0
0
0
8
0
0
0
15
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _