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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1L
All Species:
41.21
Human Site:
Y391
Identified Species:
69.74
UniProt:
Q6UB35
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UB35
NP_056255.2
978
105790
Y391
L
A
D
E
I
E
I
Y
G
K
S
K
A
K
V
Chimpanzee
Pan troglodytes
XP_518807
1117
120378
Y530
L
A
D
E
I
E
I
Y
G
K
S
K
A
K
V
Rhesus Macaque
Macaca mulatta
XP_001098522
975
105686
Y388
L
A
D
E
I
E
I
Y
G
K
S
K
A
K
V
Dog
Lupus familis
XP_533450
923
99956
Y336
L
A
D
E
I
E
I
Y
G
K
S
K
A
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q3V3R1
977
105710
Y390
L
A
D
E
I
E
I
Y
G
K
S
K
A
K
V
Rat
Rattus norvegicus
P27653
935
100977
Y348
L
T
E
E
V
E
L
Y
G
E
T
K
A
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419672
1009
108963
Y422
L
T
D
E
I
E
I
Y
G
Q
T
K
A
K
V
Frog
Xenopus laevis
NP_001080574
934
100531
Y347
L
S
Q
E
V
E
L
Y
G
Q
T
K
A
K
V
Zebra Danio
Brachydanio rerio
XP_697909
969
105090
Y382
L
P
E
E
L
E
A
Y
G
N
T
K
A
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
Y381
E
A
R
E
V
S
L
Y
G
N
K
K
A
K
I
Honey Bee
Apis mellifera
XP_623070
937
101449
Y350
L
P
N
E
I
S
P
Y
G
S
K
K
A
K
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001184686
696
75269
T139
Y
V
V
V
G
G
I
T
P
T
P
L
G
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
P77
V
V
V
G
G
I
T
P
T
P
L
G
E
G
K
Baker's Yeast
Sacchar. cerevisiae
P09440
975
106199
G377
S
H
E
L
E
L
Y
G
H
Y
K
A
K
I
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.2
97.4
87.5
N.A.
88.3
57.2
N.A.
N.A.
70.8
57.4
65.2
N.A.
50.9
49.2
N.A.
50.5
Protein Similarity:
100
87.4
98
91
N.A.
91.8
71.8
N.A.
N.A.
82.2
71.8
77
N.A.
66.2
66
N.A.
59.8
P-Site Identity:
100
100
100
100
N.A.
100
60
N.A.
N.A.
80
60
60
N.A.
46.6
53.3
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
93.3
93.3
80
N.A.
66.6
66.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
48
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.9
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
43
0
0
0
0
8
0
0
0
0
8
79
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
43
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
22
79
8
65
0
0
0
8
0
0
8
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
15
8
0
8
79
0
0
8
8
8
8
% G
% His:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
50
8
50
0
0
0
0
0
0
8
15
% I
% Lys:
0
0
0
0
0
0
0
0
0
36
22
79
8
79
8
% K
% Leu:
72
0
0
8
8
8
22
0
0
0
8
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
15
0
0
0
0
0
% N
% Pro:
0
15
0
0
0
0
8
8
8
8
8
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
15
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
8
0
0
0
15
0
0
0
8
36
0
0
0
8
% S
% Thr:
0
15
0
0
0
0
8
8
8
8
29
0
0
0
0
% T
% Val:
8
15
15
8
22
0
0
0
0
0
0
0
0
0
65
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
8
79
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _