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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD1L All Species: 30.3
Human Site: Y599 Identified Species: 51.28
UniProt: Q6UB35 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6UB35 NP_056255.2 978 105790 Y599 G N T E K G H Y R Q A Q F D I
Chimpanzee Pan troglodytes XP_518807 1117 120378 Y738 G N A E K G Y Y R Q A Q F D I
Rhesus Macaque Macaca mulatta XP_001098522 975 105686 S596 G N T E K G Y S R Q A Q F D I
Dog Lupus familis XP_533450 923 99956 S544 A P T E K G Y S R Q A Q F D I
Cat Felis silvestris
Mouse Mus musculus Q3V3R1 977 105710 S598 G S T E K G Y S R Q A Q F D I
Rat Rattus norvegicus P27653 935 100977 T556 A P T E K G H T R T A Q F D I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419672 1009 108963 V630 A N T E K G F V R Q A Q F D I
Frog Xenopus laevis NP_001080574 934 100531 T555 A P T E K G F T R T A Q F D I
Zebra Danio Brachydanio rerio XP_697909 969 105090 A590 A N T E K G H A R Q T Q F D I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96553 968 103485 S589 S P T E K G I S R E T R F S I
Honey Bee Apis mellifera XP_623070 937 101449 T558 N P T E K G K T R Q T S F C I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001184686 696 75269 L347 L K D M R E R L S K I V V A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPK5 634 67783 L285 L G D M R E R L G K M V I G N
Baker's Yeast Sacchar. cerevisiae P09440 975 106199 T585 A A T E K G F T R T T G F D I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.2 97.4 87.5 N.A. 88.3 57.2 N.A. N.A. 70.8 57.4 65.2 N.A. 50.9 49.2 N.A. 50.5
Protein Similarity: 100 87.4 98 91 N.A. 91.8 71.8 N.A. N.A. 82.2 71.8 77 N.A. 66.2 66 N.A. 59.8
P-Site Identity: 100 86.6 86.6 73.3 N.A. 80 73.3 N.A. N.A. 80 66.6 80 N.A. 46.6 53.3 N.A. 0
P-Site Similarity: 100 93.3 93.3 80 N.A. 93.3 73.3 N.A. N.A. 80 66.6 80 N.A. 60 53.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 44.6 48 N.A.
Protein Similarity: N.A. N.A. N.A. 51.9 64.1 N.A.
P-Site Identity: N.A. N.A. N.A. 0 53.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 43 8 8 0 0 0 0 8 0 0 58 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 15 0 0 0 0 0 0 0 0 0 0 72 0 % D
% Glu: 0 0 0 86 0 15 0 0 0 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 22 0 0 0 0 0 86 0 0 % F
% Gly: 29 8 0 0 0 86 0 0 8 0 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 22 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 0 8 0 8 0 86 % I
% Lys: 0 8 0 0 86 0 8 0 0 15 0 0 0 0 0 % K
% Leu: 15 0 0 0 0 0 0 15 0 0 0 0 0 0 0 % L
% Met: 0 0 0 15 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 8 36 0 0 0 0 0 0 0 0 0 0 0 0 8 % N
% Pro: 0 36 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 58 0 65 0 0 0 % Q
% Arg: 0 0 0 0 15 0 15 0 86 0 0 8 0 0 0 % R
% Ser: 8 8 0 0 0 0 0 29 8 0 0 8 0 8 8 % S
% Thr: 0 0 79 0 0 0 0 29 0 22 29 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 8 0 0 0 15 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 29 15 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _