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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK4 All Species: 16.06
Human Site: S246 Identified Species: 29.44
UniProt: Q6UW60 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6UW60 NP_060043.2 755 82795 S246 V I E A Q S L S L Q P Q H I H
Chimpanzee Pan troglodytes XP_510596 794 86649 G241 A V E A R S L G L N P N H I H
Rhesus Macaque Macaca mulatta XP_001095657 745 81119 L232 R I G G V R M L D G T I T D V
Dog Lupus familis XP_542201 757 83381 S248 V I E A Q S L S L Q P Q H I H
Cat Felis silvestris
Mouse Mus musculus P29121 655 73195 I153 G R G V V I S I L D D G I E K
Rat Rattus norvegicus Q78EH2 678 75721 D176 Y D P L A S Y D F N D Y D P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518057 567 61585 T64 R M L D G I V T D L V E A Q S
Chicken Gallus gallus NP_990046 789 86613 G242 A V E A H S L G L N P N H I H
Frog Xenopus laevis P29119 783 86425 G239 A V E A R S L G L N P N H I H
Zebra Danio Brachydanio rerio NP_001038571 806 88169 S241 V V E A Q S L S L N P Q H I D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30430 1101 120975 S460 A V E A R S L S L N P Q H I D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P51559 943 103128 S288 S V E A A S L S L N Q D H I D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 I260 E D E A A S L I Y G L D V N D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 51.7 83.7 81.3 N.A. 70.5 69.5 N.A. 45 54.2 51.7 50.7 N.A. 32.7 N.A. 36.6 N.A.
Protein Similarity: 100 64.2 86.3 86.7 N.A. 77.4 77.6 N.A. 54.2 65.6 64.6 63.9 N.A. 44.4 N.A. 49.4 N.A.
P-Site Identity: 100 60 6.6 100 N.A. 6.6 6.6 N.A. 0 60 60 80 N.A. 66.6 N.A. 53.3 N.A.
P-Site Similarity: 100 73.3 13.3 100 N.A. 6.6 6.6 N.A. 26.6 66.6 73.3 86.6 N.A. 80 N.A. 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 31 0 0 70 24 0 0 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 16 0 8 0 0 0 8 16 8 16 16 8 8 39 % D
% Glu: 8 0 70 0 0 0 0 0 0 0 0 8 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % F
% Gly: 8 0 16 8 8 0 0 24 0 16 0 8 0 0 0 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 0 62 0 39 % H
% Ile: 0 24 0 0 0 16 0 16 0 0 0 8 8 62 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % K
% Leu: 0 0 8 8 0 0 70 8 70 8 8 0 0 0 0 % L
% Met: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 54 0 24 0 8 0 % N
% Pro: 0 0 8 0 0 0 0 0 0 0 54 0 0 8 0 % P
% Gln: 0 0 0 0 24 0 0 0 0 16 8 31 0 8 0 % Q
% Arg: 16 8 0 0 24 8 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 0 0 0 77 8 39 0 0 0 0 0 0 8 % S
% Thr: 0 0 0 0 0 0 0 8 0 0 8 0 8 0 0 % T
% Val: 24 47 0 8 16 0 8 0 0 0 8 0 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 8 0 8 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _