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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
30
Human Site:
S321
Identified Species:
55
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
S321
T
N
S
I
H
T
L
S
V
G
S
T
T
Q
Q
Chimpanzee
Pan troglodytes
XP_510596
794
86649
S316
T
N
S
I
Y
T
L
S
I
S
S
A
T
Q
F
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
D307
N
G
G
L
H
Y
D
D
C
N
C
D
G
Y
T
Dog
Lupus familis
XP_542201
757
83381
S323
T
N
S
I
H
T
L
S
V
G
S
T
T
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
M228
A
R
I
G
G
V
R
M
L
D
G
A
I
T
D
Rat
Rattus norvegicus
Q78EH2
678
75721
I251
L
Q
P
Q
H
I
H
I
Y
S
A
S
W
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
G139
H
D
N
C
N
C
D
G
Y
T
N
S
I
Y
T
Chicken
Gallus gallus
NP_990046
789
86613
S317
T
N
S
I
Y
T
L
S
I
S
S
T
T
Q
Y
Frog
Xenopus laevis
P29119
783
86425
S314
T
N
S
I
Y
T
L
S
I
S
S
T
T
Q
M
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
S316
T
N
S
I
Y
T
L
S
I
S
S
S
T
Q
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
S535
T
N
S
I
W
T
L
S
I
S
S
A
T
E
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
S363
T
T
S
V
Y
T
L
S
I
S
S
A
T
Y
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
T335
T
N
S
I
Y
S
I
T
I
G
A
I
D
H
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
66.6
6.6
93.3
N.A.
0
6.6
N.A.
0
73.3
73.3
66.6
N.A.
60
N.A.
46.6
N.A.
P-Site Similarity:
100
80
13.3
93.3
N.A.
6.6
20
N.A.
33.3
86.6
86.6
86.6
N.A.
80
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
80
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
16
31
0
0
0
% A
% Cys:
0
0
0
8
0
8
0
0
8
0
8
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
16
8
0
8
0
8
8
0
16
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
8
8
8
8
0
0
8
0
24
8
0
8
8
0
% G
% His:
8
0
0
0
31
0
8
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
8
62
0
8
8
8
54
0
0
8
16
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% K
% Leu:
8
0
0
8
0
0
62
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% M
% Asn:
8
62
8
0
8
0
0
0
0
8
8
0
0
0
16
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
8
0
8
0
0
0
0
0
0
0
0
0
47
8
% Q
% Arg:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
70
0
0
8
0
62
0
54
62
24
0
0
0
% S
% Thr:
70
8
0
0
0
62
0
8
0
8
0
31
62
8
16
% T
% Val:
0
0
0
8
0
8
0
0
16
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
47
8
0
0
16
0
0
0
0
24
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _