Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK4 All Species: 29.09
Human Site: S426 Identified Species: 53.33
UniProt: Q6UW60 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6UW60 NP_060043.2 755 82795 S426 N G V G R Q V S H H Y G Y G L
Chimpanzee Pan troglodytes XP_510596 794 86649 S421 N G V G R K V S H S Y G Y G L
Rhesus Macaque Macaca mulatta XP_001095657 745 81119 I409 A Q W L T P V I T A L W E A E
Dog Lupus familis XP_542201 757 83381 S428 N G V G R Q V S H H Y G Y G L
Cat Felis silvestris
Mouse Mus musculus P29121 655 73195 P329 T T R Q G R V P W Y S E A C A
Rat Rattus norvegicus Q78EH2 678 75721 Q352 S G V V T D P Q I V T T D L H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518057 567 61585 A240 S S P A H L Q A D D W A L N G
Chicken Gallus gallus NP_990046 789 86613 S422 N G V G R K V S H S Y G Y G L
Frog Xenopus laevis P29119 783 86425 S419 N G V G R K V S H S Y G Y G L
Zebra Danio Brachydanio rerio NP_001038571 806 88169 S421 N G V G R R V S H S Y G Y G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30430 1101 120975 S640 N G V G R R V S H S F G Y G L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P51559 943 103128 G473 R M V S N K F G Y G L I D G G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 S439 S A M G K K Y S H R Y G F G K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 51.7 83.7 81.3 N.A. 70.5 69.5 N.A. 45 54.2 51.7 50.7 N.A. 32.7 N.A. 36.6 N.A.
Protein Similarity: 100 64.2 86.3 86.7 N.A. 77.4 77.6 N.A. 54.2 65.6 64.6 63.9 N.A. 44.4 N.A. 49.4 N.A.
P-Site Identity: 100 86.6 6.6 100 N.A. 6.6 13.3 N.A. 0 86.6 86.6 86.6 N.A. 80 N.A. 13.3 N.A.
P-Site Similarity: 100 93.3 6.6 100 N.A. 20 20 N.A. 20 93.3 93.3 93.3 N.A. 93.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 40 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 8 0 0 0 8 0 8 0 8 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 8 0 0 8 8 0 0 16 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 8 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 8 0 8 0 0 % F
% Gly: 0 62 0 62 8 0 0 8 0 8 0 62 0 70 16 % G
% His: 0 0 0 0 8 0 0 0 62 16 0 0 0 0 8 % H
% Ile: 0 0 0 0 0 0 0 8 8 0 0 8 0 0 0 % I
% Lys: 0 0 0 0 8 39 0 0 0 0 0 0 0 0 8 % K
% Leu: 0 0 0 8 0 8 0 0 0 0 16 0 8 8 54 % L
% Met: 0 8 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 54 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 0 0 8 0 0 8 8 8 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 8 0 16 8 8 0 0 0 0 0 0 0 % Q
% Arg: 8 0 8 0 54 24 0 0 0 8 0 0 0 0 0 % R
% Ser: 24 8 0 8 0 0 0 62 0 39 8 0 0 0 0 % S
% Thr: 8 8 0 0 16 0 0 0 8 0 8 8 0 0 0 % T
% Val: 0 0 70 8 0 0 70 0 0 8 0 0 0 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 8 0 8 8 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 8 8 54 0 54 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _