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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
8.48
Human Site:
S461
Identified Species:
15.56
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
S461
K
C
A
V
R
V
Q
S
R
P
T
P
I
L
P
Chimpanzee
Pan troglodytes
XP_510596
794
86649
T456
K
C
I
I
D
I
L
T
E
P
K
D
I
G
K
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
D444
A
G
G
S
S
P
L
D
P
P
S
P
I
L
P
Dog
Lupus familis
XP_542201
757
83381
H463
K
C
V
V
R
I
V
H
T
P
T
P
I
L
P
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
D364
D
L
H
H
Q
C
T
D
K
H
T
G
T
S
A
Rat
Rattus norvegicus
Q78EH2
678
75721
N387
I
A
L
A
L
E
A
N
P
L
L
T
W
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
M275
Q
L
A
T
E
W
K
M
S
Q
P
Q
R
K
C
Chicken
Gallus gallus
NP_990046
789
86613
T457
K
C
V
I
D
V
L
T
E
P
K
D
I
G
K
Frog
Xenopus laevis
P29119
783
86425
S454
K
Y
V
I
D
I
L
S
E
P
K
D
I
G
K
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
S456
K
C
V
L
S
L
V
S
E
P
R
N
I
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
H675
R
C
E
I
N
A
P
H
V
D
K
V
I
P
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
N508
E
Y
R
L
A
N
P
N
P
R
P
I
V
G
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
Y474
W
F
Y
L
P
T
L
Y
V
S
Q
S
T
N
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
26.6
33.3
66.6
N.A.
6.6
0
N.A.
6.6
33.3
26.6
33.3
N.A.
20
N.A.
0
N.A.
P-Site Similarity:
100
46.6
40
73.3
N.A.
20
6.6
N.A.
20
46.6
40
46.6
N.A.
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
16
8
8
8
8
0
0
0
0
0
0
0
8
% A
% Cys:
0
47
0
0
0
8
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
0
0
0
24
0
0
16
0
8
0
24
0
0
8
% D
% Glu:
8
0
8
0
8
8
0
0
31
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
8
0
0
0
0
0
0
0
0
8
0
39
0
% G
% His:
0
0
8
8
0
0
0
16
0
8
0
0
0
0
0
% H
% Ile:
8
0
8
31
0
24
0
0
0
0
0
8
62
0
0
% I
% Lys:
47
0
0
0
0
0
8
0
8
0
31
0
0
8
24
% K
% Leu:
0
16
8
24
8
8
39
0
0
8
8
0
0
24
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
8
0
16
0
0
0
8
0
8
0
% N
% Pro:
0
0
0
0
8
8
16
0
24
54
16
24
0
8
31
% P
% Gln:
8
0
0
0
8
0
8
0
0
8
8
8
0
0
0
% Q
% Arg:
8
0
8
0
16
0
0
0
8
8
8
0
8
8
8
% R
% Ser:
0
0
0
8
16
0
0
24
8
8
8
8
0
8
16
% S
% Thr:
0
0
0
8
0
8
8
16
8
0
24
8
16
0
0
% T
% Val:
0
0
31
16
0
16
16
0
16
0
0
8
8
0
0
% V
% Trp:
8
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
16
8
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _