KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
26.06
Human Site:
S499
Identified Species:
47.78
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
S499
V
Q
A
Q
L
T
L
S
Y
S
R
R
G
D
L
Chimpanzee
Pan troglodytes
XP_510596
794
86649
S494
A
Q
A
R
L
T
L
S
Y
N
R
R
G
D
L
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
S482
V
Q
A
Q
L
T
L
S
Y
S
R
R
G
D
L
Dog
Lupus familis
XP_542201
757
83381
S501
V
Q
V
Q
L
S
L
S
Y
S
R
R
G
D
L
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
A402
L
Q
H
L
V
V
R
A
S
R
P
A
Q
L
Q
Rat
Rattus norvegicus
Q78EH2
678
75721
H425
V
G
R
Q
V
S
H
H
Y
G
Y
G
L
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
L313
C
A
G
G
P
F
Q
L
R
S
L
E
H
V
Q
Chicken
Gallus gallus
NP_990046
789
86613
S495
A
Q
A
R
L
T
L
S
Y
N
R
R
G
D
L
Frog
Xenopus laevis
P29119
783
86425
S492
V
Q
A
R
L
S
L
S
Y
N
C
R
G
D
L
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
S494
V
Q
A
Q
L
T
L
S
Y
N
R
R
G
N
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
Q713
A
K
I
T
L
T
S
Q
R
R
G
D
I
Q
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
R546
V
Q
V
H
A
T
V
R
Y
L
K
R
G
D
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
V512
I
E
H
V
T
V
T
V
D
I
D
T
E
I
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
80
100
86.6
N.A.
6.6
20
N.A.
6.6
80
73.3
86.6
N.A.
20
N.A.
53.3
N.A.
P-Site Similarity:
100
93.3
100
93.3
N.A.
26.6
33.3
N.A.
6.6
93.3
93.3
100
N.A.
26.6
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
8
47
0
8
0
0
8
0
0
0
8
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
0
8
8
0
54
8
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
0
8
8
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
8
8
0
0
0
0
0
8
8
8
62
0
0
% G
% His:
0
0
16
8
0
0
8
8
0
0
0
0
8
0
0
% H
% Ile:
8
0
8
0
0
0
0
0
0
8
0
0
8
8
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% K
% Leu:
8
0
0
8
62
0
54
8
0
8
8
0
8
16
70
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
31
0
0
0
8
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
70
0
39
0
0
8
8
0
0
0
0
8
8
16
% Q
% Arg:
0
0
8
24
0
0
8
8
16
16
47
62
0
0
8
% R
% Ser:
0
0
0
0
0
24
8
54
8
31
0
0
0
0
0
% S
% Thr:
0
0
0
8
8
54
8
0
0
0
0
8
0
0
0
% T
% Val:
54
0
16
8
16
16
8
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
70
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _