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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
9.39
Human Site:
S594
Identified Species:
17.22
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
S594
T
G
P
Q
V
T
S
S
A
C
V
Q
R
D
T
Chimpanzee
Pan troglodytes
XP_510596
794
86649
T589
P
E
S
S
G
C
K
T
L
T
S
S
Q
A
C
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
S577
T
G
P
Q
V
T
S
S
A
C
V
Q
R
D
T
Dog
Lupus familis
XP_542201
757
83381
S596
P
G
P
Q
V
T
S
S
A
C
V
Q
R
D
T
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
L497
H
V
Q
V
Q
L
S
L
S
Y
S
R
R
G
D
Rat
Rattus norvegicus
Q78EH2
678
75721
V520
M
G
T
R
S
T
L
V
A
I
R
P
L
D
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
D408
L
L
Y
G
T
D
E
D
M
A
E
Q
I
L
K
Chicken
Gallus gallus
NP_990046
789
86613
C590
N
Q
L
E
S
S
G
C
K
T
L
T
P
S
Q
Frog
Xenopus laevis
P29119
783
86425
N587
F
D
G
D
G
S
R
N
V
A
S
S
Q
S
C
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
A589
T
A
G
S
S
Q
T
A
D
S
S
C
K
T
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
L808
S
Q
S
N
Q
F
N
L
Y
G
N
D
M
A
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
P641
D
P
V
Y
S
A
T
P
A
T
S
Q
G
V
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
N607
T
E
T
F
V
F
G
N
D
K
E
E
V
E
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
0
100
93.3
N.A.
13.3
26.6
N.A.
6.6
0
0
6.6
N.A.
0
N.A.
13.3
N.A.
P-Site Similarity:
100
13.3
100
93.3
N.A.
26.6
33.3
N.A.
6.6
20
20
26.6
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
8
39
16
0
0
0
16
0
% A
% Cys:
0
0
0
0
0
8
0
8
0
24
0
8
0
0
16
% C
% Asp:
8
8
0
8
0
8
0
8
16
0
0
8
0
31
8
% D
% Glu:
0
16
0
8
0
0
8
0
0
0
16
8
0
8
0
% E
% Phe:
8
0
0
8
0
16
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
31
16
8
16
0
16
0
0
8
0
0
8
8
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
8
% I
% Lys:
0
0
0
0
0
0
8
0
8
8
0
0
8
0
8
% K
% Leu:
8
8
8
0
0
8
8
16
8
0
8
0
8
8
8
% L
% Met:
8
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% M
% Asn:
8
0
0
8
0
0
8
16
0
0
8
0
0
0
0
% N
% Pro:
16
8
24
0
0
0
0
8
0
0
0
8
8
0
8
% P
% Gln:
0
16
8
24
16
8
0
0
0
0
0
39
16
0
8
% Q
% Arg:
0
0
0
8
0
0
8
0
0
0
8
8
31
0
0
% R
% Ser:
8
0
16
16
31
16
31
24
8
8
39
16
0
16
0
% S
% Thr:
31
0
16
0
8
31
16
8
0
24
0
8
0
8
24
% T
% Val:
0
8
8
8
31
0
0
8
8
0
24
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
0
0
0
8
8
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _