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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK4 All Species: 4.55
Human Site: S691 Identified Species: 8.33
UniProt: Q6UW60 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6UW60 NP_060043.2 755 82795 S691 M G P T T P D S R P R L R A A
Chimpanzee Pan troglodytes XP_510596 794 86649 P686 S Q S S R E S P P Q Q Q P P R
Rhesus Macaque Macaca mulatta XP_001095657 745 81119 S674 V G P T T P D S S P R L R A A
Dog Lupus familis XP_542201 757 83381 N693 C S G P V P P N S P P Q P T A
Cat Felis silvestris
Mouse Mus musculus P29121 655 73195 A594 A P Q V T S R A R A C V Q R D
Rat Rattus norvegicus Q78EH2 678 75721 Q617 W W L Y S H T Q Q P V T K G Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518057 567 61585 A505 H F V F N G P A Q S S A A S S
Chicken Gallus gallus NP_990046 789 86613 A687 H Q T Q S S R A S P A L V E G
Frog Xenopus laevis P29119 783 86425 P684 T Q R S R E S P T L K D S S H
Zebra Danio Brachydanio rerio NP_001038571 806 88169 Q686 C L H Q N Q I Q R E S P D G R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P30430 1101 120975 S905 P V N P Y S S S P M D H S L L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P51559 943 103128 C738 C S S H C H T C T K A E V C E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 R704 F F M K S R R R I R R S R A E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 51.7 83.7 81.3 N.A. 70.5 69.5 N.A. 45 54.2 51.7 50.7 N.A. 32.7 N.A. 36.6 N.A.
Protein Similarity: 100 64.2 86.3 86.7 N.A. 77.4 77.6 N.A. 54.2 65.6 64.6 63.9 N.A. 44.4 N.A. 49.4 N.A.
P-Site Identity: 100 0 86.6 20 N.A. 13.3 6.6 N.A. 0 13.3 0 6.6 N.A. 6.6 N.A. 0 N.A.
P-Site Similarity: 100 13.3 93.3 26.6 N.A. 33.3 26.6 N.A. 26.6 26.6 20 6.6 N.A. 6.6 N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 24 0 8 16 8 8 24 24 % A
% Cys: 24 0 0 0 8 0 0 8 0 0 8 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 16 0 0 0 8 8 8 0 8 % D
% Glu: 0 0 0 0 0 16 0 0 0 8 0 8 0 8 16 % E
% Phe: 8 16 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 16 8 0 0 8 0 0 0 0 0 0 0 16 8 % G
% His: 16 0 8 8 0 16 0 0 0 0 0 8 0 0 8 % H
% Ile: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 8 8 0 8 0 0 % K
% Leu: 0 8 8 0 0 0 0 0 0 8 0 24 0 8 8 % L
% Met: 8 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 8 0 16 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 8 8 16 16 0 24 16 16 16 39 8 8 16 8 0 % P
% Gln: 0 24 8 16 0 8 0 16 16 8 8 16 8 0 8 % Q
% Arg: 0 0 8 0 16 8 24 8 24 8 24 0 24 8 16 % R
% Ser: 8 16 16 16 24 24 24 24 24 8 16 8 16 16 8 % S
% Thr: 8 0 8 16 24 0 16 0 16 0 0 8 0 8 0 % T
% Val: 8 8 8 8 8 0 0 0 0 0 8 8 16 0 0 % V
% Trp: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _