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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
5.76
Human Site:
T658
Identified Species:
10.56
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
T658
S
C
H
A
S
C
Y
T
C
R
G
G
S
P
R
Chimpanzee
Pan troglodytes
XP_510596
794
86649
G653
A
S
C
A
T
C
Q
G
P
A
L
T
D
C
L
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
T641
S
C
H
S
S
C
Y
T
C
R
G
G
S
L
K
Dog
Lupus familis
XP_542201
757
83381
C660
S
S
C
R
A
S
C
C
P
C
R
G
G
S
P
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
Y561
G
L
E
N
K
G
Y
Y
F
N
T
G
T
L
Y
Rat
Rattus norvegicus
Q78EH2
678
75721
R584
T
A
E
D
M
T
A
R
P
Q
T
P
Q
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
R472
R
Q
Q
S
S
L
E
R
I
C
A
T
Y
H
P
Chicken
Gallus gallus
NP_990046
789
86613
C654
C
H
P
S
C
A
T
C
T
G
P
G
P
N
Q
Frog
Xenopus laevis
P29119
783
86425
G651
V
S
C
A
T
C
K
G
T
T
I
N
D
C
L
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
L653
L
P
C
H
S
V
C
L
T
C
S
G
T
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
V872
F
E
D
Q
C
Y
D
V
C
P
V
H
T
Y
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
N705
H
L
T
Q
T
L
R
N
K
G
G
S
G
F
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
S671
P
N
T
P
K
K
L
S
S
P
R
Q
A
M
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
13.3
80
13.3
N.A.
13.3
0
N.A.
6.6
6.6
13.3
13.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
26.6
93.3
20
N.A.
20
13.3
N.A.
13.3
20
20
20
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
24
8
8
8
0
0
8
8
0
8
0
0
% A
% Cys:
8
16
31
0
16
31
16
16
24
24
0
0
0
16
0
% C
% Asp:
0
0
8
8
0
0
8
0
0
0
0
0
16
0
0
% D
% Glu:
0
8
16
0
0
0
8
0
0
0
0
0
0
8
0
% E
% Phe:
8
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% F
% Gly:
8
0
0
0
0
8
0
16
0
16
24
47
16
8
0
% G
% His:
8
8
16
8
0
0
0
0
0
0
0
8
0
8
8
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
16
8
8
0
8
0
0
0
0
0
16
% K
% Leu:
8
16
0
0
0
16
8
8
0
0
8
0
0
16
16
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
8
0
8
0
0
0
8
0
8
0
8
0
8
0
% N
% Pro:
8
8
8
8
0
0
0
0
24
16
8
8
8
8
31
% P
% Gln:
0
8
8
16
0
0
8
0
0
8
0
8
8
0
8
% Q
% Arg:
8
0
0
8
0
0
8
16
0
16
16
0
0
0
8
% R
% Ser:
24
24
0
24
31
8
0
8
8
0
8
8
16
8
8
% S
% Thr:
8
0
16
0
24
8
8
16
24
8
16
16
24
0
0
% T
% Val:
8
0
0
0
0
8
0
8
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
24
8
0
0
0
0
8
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _