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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HHIPL2 All Species: 9.7
Human Site: S674 Identified Species: 23.7
UniProt: Q6UWX4 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6UWX4 NP_079022.2 724 80779 S674 K K L A S P T S S K N T L R G
Chimpanzee Pan troglodytes XP_525070 724 80720 S674 K K L A S P T S S K N T L R G
Rhesus Macaque Macaca mulatta XP_001093950 700 78823 P652 H G G V C V R P N K C L C K K
Dog Lupus familis XP_536153 696 77919 S646 R K L S N A T S A S S P D R A
Cat Felis silvestris
Mouse Mus musculus Q9D2G9 717 79980 A668 K G S L K K P A S S R S S K K
Rat Rattus norvegicus XP_229754 712 79186 K665 A P Q R G S P K K P A S P P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512074 768 85288 A673 G S S K K H V A L E S T G K L
Chicken Gallus gallus
Frog Xenopus laevis NP_001079267 995 110798 T678 T K V P P T P T Q F P T K V P
Zebra Danio Brachydanio rerio XP_688873 814 91909 T678 S A A K K K K T G Q T T T A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_794447 1074 120429 L977 R F N N E L R L T V N V D E L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 29.4 79.2 N.A. 83.1 82.1 N.A. 72 N.A. 48.5 57.3 N.A. N.A. N.A. N.A. 32.8
Protein Similarity: 100 99.7 44.2 86.3 N.A. 89.9 88.6 N.A. 80.4 N.A. 58.6 70.2 N.A. N.A. N.A. N.A. 44.9
P-Site Identity: 100 100 6.6 33.3 N.A. 13.3 0 N.A. 6.6 N.A. 13.3 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 20 66.6 N.A. 33.3 6.6 N.A. 33.3 N.A. 26.6 20 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 10 20 0 10 0 20 10 0 10 0 0 10 10 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 10 0 10 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 20 0 0 % D
% Glu: 0 0 0 0 10 0 0 0 0 10 0 0 0 10 0 % E
% Phe: 0 10 0 0 0 0 0 0 0 10 0 0 0 0 0 % F
% Gly: 10 20 10 0 10 0 0 0 10 0 0 0 10 0 20 % G
% His: 10 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 30 40 0 20 30 20 10 10 10 30 0 0 10 30 30 % K
% Leu: 0 0 30 10 0 10 0 10 10 0 0 10 20 0 20 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 10 10 0 0 0 10 0 30 0 0 0 0 % N
% Pro: 0 10 0 10 10 20 30 10 0 10 10 10 10 10 10 % P
% Gln: 0 0 10 0 0 0 0 0 10 10 0 0 0 0 0 % Q
% Arg: 20 0 0 10 0 0 20 0 0 0 10 0 0 30 0 % R
% Ser: 10 10 20 10 20 10 0 30 30 20 20 20 10 0 10 % S
% Thr: 10 0 0 0 0 10 30 20 10 0 10 50 10 0 0 % T
% Val: 0 0 10 10 0 10 10 0 0 10 0 10 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _