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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC5
All Species:
0.91
Human Site:
S427
Identified Species:
2.22
UniProt:
Q6UXY8
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UXY8
NP_001098718.1
1006
114770
S427
S
L
S
E
I
L
N
S
I
S
L
W
Q
K
T
Chimpanzee
Pan troglodytes
XP_001153396
949
108074
R417
S
I
S
R
A
Y
R
R
S
K
N
S
L
S
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_547109
928
106078
C396
R
M
F
E
L
N
C
C
A
Q
C
L
S
S
I
Cat
Felis silvestris
Mouse
Mus musculus
Q32NZ6
967
111052
N429
N
I
F
S
F
V
M
N
F
S
F
I
I
I
P
Rat
Rattus norvegicus
Q5M7W4
965
110699
N426
N
I
F
S
F
V
M
N
F
S
F
I
I
I
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
L429
K
E
N
L
S
E
R
L
Q
D
R
V
K
L
P
Chicken
Gallus gallus
Q5YCC5
735
84359
T203
T
K
I
S
P
N
N
T
E
P
Y
C
T
V
Y
Frog
Xenopus laevis
NP_001085652
725
84100
L193
I
P
Q
A
V
H
P
L
S
I
A
N
L
R
V
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395471
756
87723
N223
E
E
L
C
I
N
S
N
N
S
N
S
I
S
C
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
G353
S
G
W
D
L
L
T
G
G
G
W
F
K
D
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.3
N.A.
72.4
N.A.
73.2
73.4
N.A.
50.8
20.5
26.7
N.A.
N.A.
N.A.
21.4
N.A.
24
Protein Similarity:
100
92.8
N.A.
78.3
N.A.
80
80.9
N.A.
63.4
37
43
N.A.
N.A.
N.A.
37.9
N.A.
39.9
P-Site Identity:
100
13.3
N.A.
6.6
N.A.
6.6
6.6
N.A.
0
6.6
0
N.A.
N.A.
N.A.
13.3
N.A.
20
P-Site Similarity:
100
20
N.A.
20
N.A.
33.3
33.3
N.A.
13.3
20
13.3
N.A.
N.A.
N.A.
26.6
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
10
0
0
0
10
0
10
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
10
10
0
0
10
10
0
0
10
% C
% Asp:
0
0
0
10
0
0
0
0
0
10
0
0
0
10
0
% D
% Glu:
10
20
0
20
0
10
0
0
10
0
0
0
0
0
10
% E
% Phe:
0
0
30
0
20
0
0
0
20
0
20
10
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
10
10
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
30
10
0
20
0
0
0
10
10
0
20
30
20
10
% I
% Lys:
10
10
0
0
0
0
0
0
0
10
0
0
20
10
0
% K
% Leu:
0
10
10
10
20
20
0
20
0
0
10
10
20
10
0
% L
% Met:
0
10
0
0
0
0
20
0
0
0
0
0
0
0
0
% M
% Asn:
20
0
10
0
0
30
20
30
10
0
20
10
0
0
0
% N
% Pro:
0
10
0
0
10
0
10
0
0
10
0
0
0
0
30
% P
% Gln:
0
0
10
0
0
0
0
0
10
10
0
0
10
0
0
% Q
% Arg:
10
0
0
10
0
0
20
10
0
0
10
0
0
10
0
% R
% Ser:
30
0
20
30
10
0
10
10
20
40
0
20
10
30
0
% S
% Thr:
10
0
0
0
0
0
10
10
0
0
0
0
10
0
20
% T
% Val:
0
0
0
0
10
20
0
0
0
0
0
10
0
10
10
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
10
10
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
10
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _