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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC5
All Species:
0.61
Human Site:
Y684
Identified Species:
1.48
UniProt:
Q6UXY8
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UXY8
NP_001098718.1
1006
114770
Y684
M
F
R
L
V
E
R
Y
E
M
P
R
H
E
V
Chimpanzee
Pan troglodytes
XP_001153396
949
108074
C674
C
I
N
L
A
V
P
C
I
Y
S
T
F
R
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_547109
928
106078
L653
D
P
G
A
V
L
L
L
P
F
I
V
S
C
I
Cat
Felis silvestris
Mouse
Mus musculus
Q32NZ6
967
111052
C686
V
A
L
S
G
E
E
C
W
E
T
L
I
G
Q
Rat
Rattus norvegicus
Q5M7W4
965
110699
C683
V
A
L
S
G
E
E
C
W
E
T
L
I
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
R686
V
L
A
I
T
V
W
R
K
H
P
S
E
E
C
Chicken
Gallus gallus
Q5YCC5
735
84359
Q460
L
L
F
S
L
W
S
Q
I
H
C
D
N
D
Q
Frog
Xenopus laevis
NP_001085652
725
84100
M450
V
M
C
Y
H
W
L
M
R
K
T
K
F
L
E
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395471
756
87723
S480
S
L
I
V
L
L
T
S
F
Y
R
L
I
V
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
L610
V
D
F
I
L
Q
S
L
A
T
F
V
L
E
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.3
N.A.
72.4
N.A.
73.2
73.4
N.A.
50.8
20.5
26.7
N.A.
N.A.
N.A.
21.4
N.A.
24
Protein Similarity:
100
92.8
N.A.
78.3
N.A.
80
80.9
N.A.
63.4
37
43
N.A.
N.A.
N.A.
37.9
N.A.
39.9
P-Site Identity:
100
6.6
N.A.
6.6
N.A.
6.6
6.6
N.A.
13.3
0
0
N.A.
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
100
13.3
N.A.
13.3
N.A.
13.3
13.3
N.A.
33.3
26.6
13.3
N.A.
N.A.
N.A.
13.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
10
10
10
0
0
0
10
0
0
0
0
0
0
% A
% Cys:
10
0
10
0
0
0
0
30
0
0
10
0
0
10
10
% C
% Asp:
10
10
0
0
0
0
0
0
0
0
0
10
0
10
0
% D
% Glu:
0
0
0
0
0
30
20
0
10
20
0
0
10
30
10
% E
% Phe:
0
10
20
0
0
0
0
0
10
10
10
0
20
0
10
% F
% Gly:
0
0
10
0
20
0
0
0
0
0
0
0
0
20
0
% G
% His:
0
0
0
0
10
0
0
0
0
20
0
0
10
0
0
% H
% Ile:
0
10
10
20
0
0
0
0
20
0
10
0
30
0
10
% I
% Lys:
0
0
0
0
0
0
0
0
10
10
0
10
0
0
0
% K
% Leu:
10
30
20
20
30
20
20
20
0
0
0
30
10
10
10
% L
% Met:
10
10
0
0
0
0
0
10
0
10
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
10
0
0
0
0
10
0
10
0
20
0
0
0
0
% P
% Gln:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
30
% Q
% Arg:
0
0
10
0
0
0
10
10
10
0
10
10
0
10
0
% R
% Ser:
10
0
0
30
0
0
20
10
0
0
10
10
10
0
0
% S
% Thr:
0
0
0
0
10
0
10
0
0
10
30
10
0
0
10
% T
% Val:
50
0
0
10
20
20
0
0
0
0
0
20
0
10
10
% V
% Trp:
0
0
0
0
0
20
10
0
20
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
0
10
0
20
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _