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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPLB
All Species:
13.33
Human Site:
S245
Identified Species:
24.44
UniProt:
Q6Y1H2
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6Y1H2
NP_940684.1
254
28368
S245
H
Q
R
R
K
I
L
S
H
T
E
E
H
K
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113078
254
28296
S245
H
Q
R
R
K
I
L
S
H
T
E
E
H
K
K
Dog
Lupus familis
XP_850968
216
25210
H208
Q
R
R
K
V
L
S
H
T
E
E
H
K
K
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9D3B1
254
28384
S245
H
Q
R
R
K
V
L
S
H
T
E
E
H
K
K
Rat
Rattus norvegicus
XP_213610
254
28333
S245
Q
Q
R
R
K
V
L
S
H
T
E
E
H
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519816
207
23678
P199
R
Q
R
R
M
L
S
P
R
L
M
G
T
Q
E
Chicken
Gallus gallus
Q5ZM57
362
42817
L354
Y
K
Q
R
K
Q
H
L
G
P
K
K
R
K
M
Frog
Xenopus laevis
Q6GNB5
218
25718
Q210
S
E
R
K
Q
Y
F
Q
R
K
L
K
L
K
K
Zebra Danio
Brachydanio rerio
Q7SY06
359
42393
F351
F
K
Q
R
T
R
R
F
R
T
K
K
R
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_504740
218
24628
L210
I
G
Q
R
K
K
I
L
G
G
G
S
K
K
K
Sea Urchin
Strong. purpuratus
XP_796799
235
26468
G226
R
Q
R
K
K
L
I
G
G
G
A
P
G
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZB2
221
25308
R213
Y
M
L
G
Q
R
K
R
A
L
S
K
S
K
R
Baker's Yeast
Sacchar. cerevisiae
P40857
217
24492
R209
K
K
V
M
K
S
L
R
S
S
F
G
K
K
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.2
81
N.A.
94.8
93.6
N.A.
49.6
21.2
24
22.2
N.A.
N.A.
N.A.
40.9
56.6
Protein Similarity:
100
N.A.
99.6
83.4
N.A.
98
97.6
N.A.
58.2
38.9
42.9
40.6
N.A.
N.A.
N.A.
56.2
71.2
P-Site Identity:
100
N.A.
100
20
N.A.
93.3
86.6
N.A.
20
20
20
20
N.A.
N.A.
N.A.
26.6
26.6
P-Site Similarity:
100
N.A.
100
40
N.A.
100
93.3
N.A.
40
53.3
46.6
46.6
N.A.
N.A.
N.A.
40
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.4
30.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.9
48.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
8
39
31
0
0
8
% E
% Phe:
8
0
0
0
0
0
8
8
0
0
8
0
0
0
8
% F
% Gly:
0
8
0
8
0
0
0
8
24
16
8
16
8
0
0
% G
% His:
24
0
0
0
0
0
8
8
31
0
0
8
31
0
0
% H
% Ile:
8
0
0
0
0
16
16
0
0
0
0
0
0
0
0
% I
% Lys:
8
24
0
24
62
8
8
0
0
8
16
31
24
85
54
% K
% Leu:
0
0
8
0
0
24
39
16
0
16
8
0
8
0
8
% L
% Met:
0
8
0
8
8
0
0
0
0
0
8
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
8
0
8
0
8
0
0
0
% P
% Gln:
16
47
24
0
16
8
0
8
0
0
0
0
0
8
0
% Q
% Arg:
16
8
62
62
0
16
8
16
24
0
0
0
16
0
8
% R
% Ser:
8
0
0
0
0
8
16
31
8
8
8
8
8
0
0
% S
% Thr:
0
0
0
0
8
0
0
0
8
39
0
0
8
8
0
% T
% Val:
0
0
8
0
8
16
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _