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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: THADA All Species: 6.36
Human Site: S1858 Identified Species: 14
UniProt: Q6YHU6 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6YHU6 NP_001077422.1 1953 219607 S1858 L F C L L S K S G W R P P S P
Chimpanzee Pan troglodytes XP_001141732 1953 219528 S1858 L F C L L S K S G W R P P S P
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus A8C756 1938 217270 F1842 K S L C R Q L F H L L C Q S G
Rat Rattus norvegicus XP_233829 1937 217220 V1841 V K Y L C N Q V F H L L C Q S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513110 1056 113729 A965 E G Y G A R A A V G P G H I G
Chicken Gallus gallus A8C754 1930 216561 L1837 V N F W A E K L T S A R L L G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608361 1746 197334 M1655 Q E Q E Q S A M A P L I L P S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797130 1666 185673 S1575 L I R V M E Q S T C Q G S D G
Poplar Tree Populus trichocarpa XP_002305983 2134 240562 K2000 L E Q L P I S K S W L A D G P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_191076 2149 242725 A1897 S R W V F N T A D Y T S P P K
Baker's Yeast Sacchar. cerevisiae Q03496 1420 163559 M1329 I N E L Q K A M H I L N M I K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 N.A. N.A. N.A. 78.4 79.2 N.A. 30.9 58.1 N.A. N.A. N.A. 21.7 N.A. N.A. 23.4
Protein Similarity: 100 99.4 N.A. N.A. N.A. 87.4 87.5 N.A. 39.8 73 N.A. N.A. N.A. 40.1 N.A. N.A. 40.5
P-Site Identity: 100 100 N.A. N.A. N.A. 6.6 6.6 N.A. 0 6.6 N.A. N.A. N.A. 6.6 N.A. N.A. 13.3
P-Site Similarity: 100 100 N.A. N.A. N.A. 6.6 26.6 N.A. 6.6 13.3 N.A. N.A. N.A. 6.6 N.A. N.A. 40
Percent
Protein Identity: 20.4 N.A. N.A. 20.8 21.2 N.A.
Protein Similarity: 39 N.A. N.A. 39.9 38.7 N.A.
P-Site Identity: 26.6 N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: 26.6 N.A. N.A. 33.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 19 0 28 19 10 0 10 10 0 0 0 % A
% Cys: 0 0 19 10 10 0 0 0 0 10 0 10 10 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 10 0 0 0 10 10 0 % D
% Glu: 10 19 10 10 0 19 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 19 10 0 10 0 0 10 10 0 0 0 0 0 0 % F
% Gly: 0 10 0 10 0 0 0 0 19 10 0 19 0 10 37 % G
% His: 0 0 0 0 0 0 0 0 19 10 0 0 10 0 0 % H
% Ile: 10 10 0 0 0 10 0 0 0 10 0 10 0 19 0 % I
% Lys: 10 10 0 0 0 10 28 10 0 0 0 0 0 0 19 % K
% Leu: 37 0 10 46 19 0 10 10 0 10 46 10 19 10 0 % L
% Met: 0 0 0 0 10 0 0 19 0 0 0 0 10 0 0 % M
% Asn: 0 19 0 0 0 19 0 0 0 0 0 10 0 0 0 % N
% Pro: 0 0 0 0 10 0 0 0 0 10 10 19 28 19 28 % P
% Gln: 10 0 19 0 19 10 19 0 0 0 10 0 10 10 0 % Q
% Arg: 0 10 10 0 10 10 0 0 0 0 19 10 0 0 0 % R
% Ser: 10 10 0 0 0 28 10 28 10 10 0 10 10 28 19 % S
% Thr: 0 0 0 0 0 0 10 0 19 0 10 0 0 0 0 % T
% Val: 19 0 0 19 0 0 0 10 10 0 0 0 0 0 0 % V
% Trp: 0 0 10 10 0 0 0 0 0 28 0 0 0 0 0 % W
% Tyr: 0 0 19 0 0 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _