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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K15
All Species:
8.18
Human Site:
S503
Identified Species:
22.5
UniProt:
Q6ZN16
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN16
NP_001001671.2
1313
147437
S503
K
K
T
I
I
E
H
S
P
R
Q
E
R
L
N
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
P533
V
K
L
T
T
E
Q
P
V
A
K
Q
E
L
V
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
R495
R
P
M
P
A
E
P
R
G
G
P
P
R
R
A
Dog
Lupus familis
XP_548885
1422
158482
S599
K
K
S
I
T
E
H
S
P
R
Q
E
R
L
N
Cat
Felis silvestris
Mouse
Mus musculus
A2AQW0
1331
149309
S507
K
K
P
I
T
E
H
S
P
R
Q
E
R
L
N
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514080
1407
157705
L577
S
L
V
Q
N
L
L
L
I
Q
R
F
R
K
L
Chicken
Gallus gallus
XP_419725
1260
143069
Q457
L
E
P
T
K
I
Y
Q
P
S
Y
L
S
I
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
Q519
T
K
V
S
T
D
P
Q
A
P
K
Q
E
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
F463
E
S
T
T
D
L
R
F
P
V
L
V
L
E
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58
44.2
81.6
N.A.
86
N.A.
N.A.
70.8
57.3
N.A.
54.4
N.A.
N.A.
N.A.
N.A.
45.4
Protein Similarity:
100
72.6
60.9
86.4
N.A.
90.3
N.A.
N.A.
79.4
73.5
N.A.
71.5
N.A.
N.A.
N.A.
N.A.
62.2
P-Site Identity:
100
20
13.3
86.6
N.A.
86.6
N.A.
N.A.
6.6
13.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
33.3
20
93.3
N.A.
86.6
N.A.
N.A.
20
33.3
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
0
0
12
12
0
0
0
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
12
12
0
0
0
0
0
0
0
0
0
% D
% Glu:
12
12
0
0
0
56
0
0
0
0
0
34
23
12
0
% E
% Phe:
0
0
0
0
0
0
0
12
0
0
0
12
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
12
12
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
34
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
34
12
12
0
0
12
0
0
0
0
12
0
% I
% Lys:
34
56
0
0
12
0
0
0
0
0
23
0
0
12
0
% K
% Leu:
12
12
12
0
0
23
12
12
0
0
12
12
12
56
12
% L
% Met:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
45
% N
% Pro:
0
12
23
12
0
0
23
12
56
12
12
12
0
0
12
% P
% Gln:
0
0
0
12
0
0
12
23
0
12
34
23
0
0
0
% Q
% Arg:
12
0
0
0
0
0
12
12
0
34
12
0
56
12
0
% R
% Ser:
12
12
12
12
0
0
0
34
0
12
0
0
12
0
0
% S
% Thr:
12
0
23
34
45
0
0
0
0
0
0
0
0
0
0
% T
% Val:
12
0
23
0
0
0
0
0
12
12
0
12
0
0
23
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
12
0
0
0
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _