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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K15
All Species:
10
Human Site:
T1257
Identified Species:
27.5
UniProt:
Q6ZN16
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN16
NP_001001671.2
1313
147437
T1257
L
Q
G
A
D
A
K
T
I
E
K
I
V
E
E
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
L1318
D
S
E
L
T
D
W
L
R
V
N
G
A
D
E
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
T1239
E
L
N
V
D
S
G
T
I
Q
M
L
L
N
H
Dog
Lupus familis
XP_548885
1422
158482
T1352
L
Q
G
A
D
S
S
T
I
E
K
I
V
E
E
Cat
Felis silvestris
Mouse
Mus musculus
A2AQW0
1331
149309
G1274
I
D
W
L
Q
L
Q
G
V
D
A
N
T
I
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514080
1407
157705
T1352
R
Q
G
A
D
T
A
T
I
E
K
I
V
E
E
Chicken
Gallus gallus
XP_419725
1260
143069
L1203
D
P
D
L
I
N
W
L
S
V
Q
G
A
D
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
W1306
G
D
L
Q
L
L
E
W
L
K
L
H
G
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
W1228
K
Q
E
E
L
S
S
W
L
Q
A
V
G
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58
44.2
81.6
N.A.
86
N.A.
N.A.
70.8
57.3
N.A.
54.4
N.A.
N.A.
N.A.
N.A.
45.4
Protein Similarity:
100
72.6
60.9
86.4
N.A.
90.3
N.A.
N.A.
79.4
73.5
N.A.
71.5
N.A.
N.A.
N.A.
N.A.
62.2
P-Site Identity:
100
6.6
20
86.6
N.A.
6.6
N.A.
N.A.
80
6.6
N.A.
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
13.3
46.6
93.3
N.A.
33.3
N.A.
N.A.
80
20
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
34
0
12
12
0
0
0
23
0
23
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
23
23
12
0
45
12
0
0
0
12
0
0
0
23
23
% D
% Glu:
12
0
23
12
0
0
12
0
0
34
0
0
0
34
67
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
0
34
0
0
0
12
12
0
0
0
23
23
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
12
% H
% Ile:
12
0
0
0
12
0
0
0
45
0
0
34
0
12
0
% I
% Lys:
12
0
0
0
0
0
12
0
0
12
34
0
0
0
0
% K
% Leu:
23
12
12
34
23
23
0
23
23
0
12
12
12
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% M
% Asn:
0
0
12
0
0
12
0
0
0
0
12
12
0
12
0
% N
% Pro:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
45
0
12
12
0
12
0
0
23
12
0
0
0
0
% Q
% Arg:
12
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% R
% Ser:
0
12
0
0
0
34
23
0
12
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
12
12
0
45
0
0
0
0
12
0
0
% T
% Val:
0
0
0
12
0
0
0
0
12
23
0
12
34
0
0
% V
% Trp:
0
0
12
0
0
0
23
23
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _