KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF8
All Species:
3.64
Human Site:
S127
Identified Species:
6.15
UniProt:
Q6ZN54
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN54
NP_060172.1
512
58710
S127
R
V
M
D
L
G
L
S
E
D
H
F
S
R
P
Chimpanzee
Pan troglodytes
XP_523472
386
44371
V83
E
F
R
C
P
E
R
V
M
D
L
G
L
S
E
Rhesus Macaque
Macaca mulatta
XP_001092097
445
51385
K107
P
E
Q
S
E
K
Q
K
D
A
V
V
R
L
I
Dog
Lupus familis
XP_546771
474
55061
V118
A
I
E
E
C
K
Q
V
I
L
E
L
P
E
H
Cat
Felis silvestris
Mouse
Mus musculus
Q99J78
448
52292
R109
K
Q
K
D
A
V
V
R
L
I
H
L
R
L
K
Rat
Rattus norvegicus
Q4V8I4
451
52679
D108
E
Q
S
E
K
Q
K
D
A
V
V
R
L
I
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510872
428
48058
V116
A
I
E
E
C
K
Q
V
I
L
E
L
P
E
H
Chicken
Gallus gallus
XP_001232734
209
24170
Frog
Xenopus laevis
Q6DDJ3
443
51304
R108
R
Q
K
D
A
V
V
R
L
I
H
L
R
L
K
Zebra Danio
Brachydanio rerio
NP_001007396
286
33384
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTT9
492
55389
D121
W
L
V
R
H
L
V
D
L
R
Y
S
L
Q
E
Honey Bee
Apis mellifera
XP_393689
483
55355
A110
K
Q
M
V
L
E
S
A
E
C
S
D
E
R
K
Nematode Worm
Caenorhab. elegans
O01738
486
56489
N113
D
V
L
G
N
L
V
N
C
L
D
R
Q
Q
K
Sea Urchin
Strong. purpuratus
XP_781480
596
67870
T243
E
D
L
G
V
G
L
T
E
N
H
F
S
Q
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57
83.5
85.7
N.A.
82
81.8
N.A.
38.2
35.5
71
40.2
N.A.
32.8
33.4
31.2
38.9
Protein Similarity:
100
61.5
84.5
87.6
N.A.
84.1
84.5
N.A.
50.9
38.6
77.9
48.2
N.A.
50.3
51.9
46.2
55.3
P-Site Identity:
100
6.6
0
0
N.A.
13.3
0
N.A.
0
0
20
0
N.A.
0
26.6
6.6
46.6
P-Site Similarity:
100
6.6
6.6
13.3
N.A.
26.6
6.6
N.A.
13.3
0
26.6
0
N.A.
33.3
40
33.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
15
0
0
8
8
8
0
0
0
0
0
% A
% Cys:
0
0
0
8
15
0
0
0
8
8
0
0
0
0
0
% C
% Asp:
8
8
0
22
0
0
0
15
8
15
8
8
0
0
0
% D
% Glu:
22
8
15
22
8
15
0
0
22
0
15
0
8
15
15
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
15
0
0
0
% F
% Gly:
0
0
0
15
0
15
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
29
0
0
0
22
% H
% Ile:
0
15
0
0
0
0
0
0
15
15
0
0
0
8
8
% I
% Lys:
15
0
15
0
8
22
8
8
0
0
0
0
0
0
29
% K
% Leu:
0
8
15
0
15
15
15
0
22
22
8
29
22
22
0
% L
% Met:
0
0
15
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
8
0
8
0
0
0
0
0
% N
% Pro:
8
0
0
0
8
0
0
0
0
0
0
0
15
0
15
% P
% Gln:
0
29
8
0
0
8
22
0
0
0
0
0
8
22
0
% Q
% Arg:
15
0
8
8
0
0
8
15
0
8
0
15
22
15
0
% R
% Ser:
0
0
8
8
0
0
8
8
0
0
8
8
15
8
0
% S
% Thr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
15
8
8
8
15
29
22
0
8
15
8
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _