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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF8
All Species:
5.45
Human Site:
S253
Identified Species:
9.23
UniProt:
Q6ZN54
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN54
NP_060172.1
512
58710
S253
I
S
K
P
C
V
S
S
K
V
S
H
Q
A
E
Chimpanzee
Pan troglodytes
XP_523472
386
44371
D177
K
S
V
K
Q
T
C
D
K
C
N
A
I
I
W
Rhesus Macaque
Macaca mulatta
XP_001092097
445
51385
L202
S
H
Q
A
E
Y
E
L
N
I
C
P
E
T
G
Dog
Lupus familis
XP_546771
474
55061
S215
I
S
K
P
C
V
R
S
K
V
S
H
Q
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q99J78
448
52292
P203
E
Y
E
L
N
I
C
P
E
T
G
L
D
S
Q
Rat
Rattus norvegicus
Q4V8I4
451
52679
L202
S
H
Q
A
E
Y
E
L
N
I
C
P
E
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510872
428
48058
L213
C
L
D
G
G
A
E
L
K
L
R
Q
D
I
L
Chicken
Gallus gallus
XP_001232734
209
24170
Frog
Xenopus laevis
Q6DDJ3
443
51304
P202
E
Y
E
L
S
I
C
P
E
A
G
L
D
S
Q
Zebra Danio
Brachydanio rerio
NP_001007396
286
33384
E77
L
F
V
V
S
D
V
E
Q
L
K
L
A
I
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTT9
492
55389
V217
V
K
R
V
C
A
H
V
L
V
S
E
R
Q
H
Honey Bee
Apis mellifera
XP_393689
483
55355
A208
R
V
C
V
H
V
V
A
S
E
A
G
G
Y
T
Nematode Worm
Caenorhab. elegans
O01738
486
56489
L216
K
R
V
C
A
G
V
L
S
T
R
A
K
F
E
Sea Urchin
Strong. purpuratus
XP_781480
596
67870
S370
L
V
K
R
K
C
V
S
A
K
I
S
R
P
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57
83.5
85.7
N.A.
82
81.8
N.A.
38.2
35.5
71
40.2
N.A.
32.8
33.4
31.2
38.9
Protein Similarity:
100
61.5
84.5
87.6
N.A.
84.1
84.5
N.A.
50.9
38.6
77.9
48.2
N.A.
50.3
51.9
46.2
55.3
P-Site Identity:
100
13.3
0
93.3
N.A.
0
0
N.A.
6.6
0
0
6.6
N.A.
20
6.6
6.6
13.3
P-Site Similarity:
100
20
20
93.3
N.A.
33.3
20
N.A.
13.3
0
33.3
26.6
N.A.
40
20
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
8
15
0
8
8
8
8
15
8
15
0
% A
% Cys:
8
0
8
8
22
8
22
0
0
8
15
0
0
0
8
% C
% Asp:
0
0
8
0
0
8
0
8
0
0
0
0
22
0
0
% D
% Glu:
15
0
15
0
15
0
22
8
15
8
0
8
15
0
29
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
8
8
8
0
0
0
0
15
8
8
0
15
% G
% His:
0
15
0
0
8
0
8
0
0
0
0
15
0
0
8
% H
% Ile:
15
0
0
0
0
15
0
0
0
15
8
0
8
22
0
% I
% Lys:
15
8
22
8
8
0
0
0
29
8
8
0
8
0
0
% K
% Leu:
15
8
0
15
0
0
0
29
8
15
0
22
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
15
0
8
0
0
0
0
% N
% Pro:
0
0
0
15
0
0
0
15
0
0
0
15
0
8
0
% P
% Gln:
0
0
15
0
8
0
0
0
8
0
0
8
15
8
15
% Q
% Arg:
8
8
8
8
0
0
8
0
0
0
15
0
15
0
0
% R
% Ser:
15
22
0
0
15
0
8
22
15
0
22
8
0
15
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
15
0
0
0
15
8
% T
% Val:
8
15
22
22
0
22
29
8
0
22
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
15
0
0
0
15
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _