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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF8
All Species:
9.7
Human Site:
S273
Identified Species:
16.41
UniProt:
Q6ZN54
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN54
NP_060172.1
512
58710
S273
C
P
E
T
G
L
D
S
Q
D
Y
R
C
A
E
Chimpanzee
Pan troglodytes
XP_523472
386
44371
Y197
W
Y
T
C
T
G
C
Y
Y
R
C
H
S
K
C
Rhesus Macaque
Macaca mulatta
XP_001092097
445
51385
A222
Y
R
C
A
E
C
R
A
P
I
S
L
R
G
V
Dog
Lupus familis
XP_546771
474
55061
S235
C
P
E
T
G
L
D
S
Q
D
Y
R
C
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q99J78
448
52292
L223
E
C
R
A
P
I
S
L
R
G
V
P
S
E
A
Rat
Rattus norvegicus
Q4V8I4
451
52679
A222
Y
R
C
A
E
C
R
A
P
I
S
L
R
G
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510872
428
48058
M233
F
I
T
C
K
E
A
M
E
A
R
L
L
L
Q
Chicken
Gallus gallus
XP_001232734
209
24170
L20
E
P
N
I
R
V
V
L
E
H
R
F
Y
K
E
Frog
Xenopus laevis
Q6DDJ3
443
51304
L222
E
C
R
T
P
I
S
L
R
A
V
P
S
E
A
Zebra Danio
Brachydanio rerio
NP_001007396
286
33384
S97
I
L
E
L
P
E
H
S
E
K
Q
R
D
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTT9
492
55389
S237
C
P
E
I
G
L
A
S
Q
G
Y
K
C
A
E
Honey Bee
Apis mellifera
XP_393689
483
55355
N228
C
P
E
Q
G
L
S
N
Q
G
Y
R
C
A
E
Nematode Worm
Caenorhab. elegans
O01738
486
56489
E236
C
E
E
R
S
L
A
E
Q
E
Y
Q
C
A
E
Sea Urchin
Strong. purpuratus
XP_781480
596
67870
A390
C
P
E
K
G
L
S
A
Q
K
Y
R
C
A
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57
83.5
85.7
N.A.
82
81.8
N.A.
38.2
35.5
71
40.2
N.A.
32.8
33.4
31.2
38.9
Protein Similarity:
100
61.5
84.5
87.6
N.A.
84.1
84.5
N.A.
50.9
38.6
77.9
48.2
N.A.
50.3
51.9
46.2
55.3
P-Site Identity:
100
0
0
100
N.A.
0
0
N.A.
0
13.3
6.6
26.6
N.A.
73.3
73.3
53.3
73.3
P-Site Similarity:
100
0
6.6
100
N.A.
13.3
6.6
N.A.
13.3
26.6
20
33.3
N.A.
80
80
66.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
22
0
0
22
22
0
15
0
0
0
50
15
% A
% Cys:
43
15
15
15
0
15
8
0
0
0
8
0
43
0
8
% C
% Asp:
0
0
0
0
0
0
15
0
0
15
0
0
8
0
0
% D
% Glu:
22
8
50
0
15
15
0
8
22
8
0
0
0
15
50
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
36
8
0
0
0
22
0
0
0
15
0
% G
% His:
0
0
0
0
0
0
8
0
0
8
0
8
0
0
0
% H
% Ile:
8
8
0
15
0
15
0
0
0
15
0
0
0
0
0
% I
% Lys:
0
0
0
8
8
0
0
0
0
15
0
8
0
15
0
% K
% Leu:
0
8
0
8
0
43
0
22
0
0
0
22
8
8
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
43
0
0
22
0
0
0
15
0
0
15
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
0
43
0
8
8
0
0
8
% Q
% Arg:
0
15
15
8
8
0
15
0
15
8
15
36
15
0
0
% R
% Ser:
0
0
0
0
8
0
29
29
0
0
15
0
22
0
0
% S
% Thr:
0
0
15
22
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
8
0
0
0
15
0
0
0
22
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
15
8
0
0
0
0
0
8
8
0
43
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _