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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF8
All Species:
21.82
Human Site:
S496
Identified Species:
36.92
UniProt:
Q6ZN54
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN54
NP_060172.1
512
58710
S496
C
P
K
C
A
R
L
S
L
R
K
Q
S
L
F
Chimpanzee
Pan troglodytes
XP_523472
386
44371
Q374
A
R
L
S
L
R
K
Q
S
L
F
Q
E
P
G
Rhesus Macaque
Macaca mulatta
XP_001092097
445
51385
S429
C
P
K
C
A
R
L
S
L
R
K
Q
S
L
F
Dog
Lupus familis
XP_546771
474
55061
T458
C
P
K
C
A
R
L
T
L
R
K
Q
S
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q99J78
448
52292
T432
C
P
K
C
A
R
L
T
L
R
K
Q
S
L
F
Rat
Rattus norvegicus
Q4V8I4
451
52679
T435
C
P
K
C
A
R
L
T
L
R
K
Q
S
L
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510872
428
48058
E416
F
S
G
P
N
Y
V
E
G
T
S
A
A
V
P
Chicken
Gallus gallus
XP_001232734
209
24170
G197
R
A
H
R
L
S
P
G
E
E
Q
G
Q
H
Q
Frog
Xenopus laevis
Q6DDJ3
443
51304
S431
C
P
R
C
M
R
L
S
L
R
K
Q
T
Q
N
Zebra Danio
Brachydanio rerio
NP_001007396
286
33384
I274
I
T
Q
L
C
V
H
I
V
R
E
C
W
N
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTT9
492
55389
Q460
C
P
K
C
I
R
I
Q
E
R
R
L
Q
L
D
Honey Bee
Apis mellifera
XP_393689
483
55355
Q451
C
P
R
C
T
R
L
Q
K
R
R
A
L
Q
D
Nematode Worm
Caenorhab. elegans
O01738
486
56489
R466
C
P
R
C
E
R
R
R
K
R
T
E
I
P
K
Sea Urchin
Strong. purpuratus
XP_781480
596
67870
A584
L
F
P
F
D
M
I
A
T
L
C
A
N
C
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57
83.5
85.7
N.A.
82
81.8
N.A.
38.2
35.5
71
40.2
N.A.
32.8
33.4
31.2
38.9
Protein Similarity:
100
61.5
84.5
87.6
N.A.
84.1
84.5
N.A.
50.9
38.6
77.9
48.2
N.A.
50.3
51.9
46.2
55.3
P-Site Identity:
100
13.3
100
93.3
N.A.
93.3
93.3
N.A.
0
0
66.6
6.6
N.A.
46.6
40
33.3
0
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
20
6.6
80
26.6
N.A.
60
53.3
46.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
36
0
0
8
0
0
0
22
8
0
0
% A
% Cys:
65
0
0
65
8
0
0
0
0
0
8
8
0
8
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
15
% D
% Glu:
0
0
0
0
8
0
0
8
15
8
8
8
8
0
0
% E
% Phe:
8
8
0
8
0
0
0
0
0
0
8
0
0
0
36
% F
% Gly:
0
0
8
0
0
0
0
8
8
0
0
8
0
0
8
% G
% His:
0
0
8
0
0
0
8
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
0
0
8
0
15
8
0
0
0
0
8
0
0
% I
% Lys:
0
0
43
0
0
0
8
0
15
0
43
0
0
0
8
% K
% Leu:
8
0
8
8
15
0
50
0
43
15
0
8
8
43
0
% L
% Met:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
8
8
8
% N
% Pro:
0
65
8
8
0
0
8
0
0
0
0
0
0
15
8
% P
% Gln:
0
0
8
0
0
0
0
22
0
0
8
50
15
15
8
% Q
% Arg:
8
8
22
8
0
72
8
8
0
72
15
0
0
0
0
% R
% Ser:
0
8
0
8
0
8
0
22
8
0
8
0
36
0
8
% S
% Thr:
0
8
0
0
8
0
0
22
8
8
8
0
8
0
8
% T
% Val:
0
0
0
0
0
8
8
0
8
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _