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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DEF8
All Species:
32.73
Human Site:
Y409
Identified Species:
55.38
UniProt:
Q6ZN54
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN54
NP_060172.1
512
58710
Y409
F
V
E
N
D
E
M
Y
S
V
Q
D
L
L
D
Chimpanzee
Pan troglodytes
XP_523472
386
44371
A306
P
C
V
L
A
E
E
A
C
L
P
P
P
C
L
Rhesus Macaque
Macaca mulatta
XP_001092097
445
51385
Y342
F
V
E
N
D
E
M
Y
S
V
Q
D
L
L
D
Dog
Lupus familis
XP_546771
474
55061
Y371
F
V
E
N
D
E
M
Y
S
I
Q
D
L
L
D
Cat
Felis silvestris
Mouse
Mus musculus
Q99J78
448
52292
Y345
F
V
E
N
D
E
M
Y
S
I
Q
D
L
L
E
Rat
Rattus norvegicus
Q4V8I4
451
52679
Y348
F
V
E
N
D
E
M
Y
S
I
Q
D
L
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510872
428
48058
P348
P
P
P
S
S
S
F
P
D
L
G
R
P
R
I
Chicken
Gallus gallus
XP_001232734
209
24170
S129
T
G
L
Y
Y
C
S
S
C
H
W
N
D
L
A
Frog
Xenopus laevis
Q6DDJ3
443
51304
Y344
F
V
E
N
D
D
M
Y
S
L
Q
D
L
L
D
Zebra Danio
Brachydanio rerio
NP_001007396
286
33384
K206
C
P
E
I
G
L
D
K
Q
D
Y
R
C
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTT9
492
55389
Y374
L
A
Q
S
N
E
F
Y
S
L
S
D
L
S
Q
Honey Bee
Apis mellifera
XP_393689
483
55355
Y364
M
I
E
N
S
G
N
Y
S
I
K
D
L
I
D
Nematode Worm
Caenorhab. elegans
O01738
486
56489
Y373
F
V
D
N
S
V
M
Y
S
P
K
E
L
R
E
Sea Urchin
Strong. purpuratus
XP_781480
596
67870
R516
L
L
K
Q
L
Q
V
R
P
H
F
V
E
N
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57
83.5
85.7
N.A.
82
81.8
N.A.
38.2
35.5
71
40.2
N.A.
32.8
33.4
31.2
38.9
Protein Similarity:
100
61.5
84.5
87.6
N.A.
84.1
84.5
N.A.
50.9
38.6
77.9
48.2
N.A.
50.3
51.9
46.2
55.3
P-Site Identity:
100
6.6
100
93.3
N.A.
86.6
86.6
N.A.
0
6.6
86.6
6.6
N.A.
33.3
46.6
46.6
0
P-Site Similarity:
100
13.3
100
100
N.A.
100
100
N.A.
13.3
13.3
100
13.3
N.A.
60
73.3
73.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
8
0
0
0
0
0
0
8
% A
% Cys:
8
8
0
0
0
8
0
0
15
0
0
0
8
8
0
% C
% Asp:
0
0
8
0
43
8
8
0
8
8
0
58
8
0
36
% D
% Glu:
0
0
58
0
0
50
8
0
0
0
0
8
8
0
29
% E
% Phe:
50
0
0
0
0
0
15
0
0
0
8
0
0
0
0
% F
% Gly:
0
8
0
0
8
8
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% H
% Ile:
0
8
0
8
0
0
0
0
0
29
0
0
0
8
8
% I
% Lys:
0
0
8
0
0
0
0
8
0
0
15
0
0
0
0
% K
% Leu:
15
8
8
8
8
8
0
0
0
29
0
0
65
50
8
% L
% Met:
8
0
0
0
0
0
50
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
58
8
0
8
0
0
0
0
8
0
8
0
% N
% Pro:
15
15
8
0
0
0
0
8
8
8
8
8
15
0
0
% P
% Gln:
0
0
8
8
0
8
0
0
8
0
43
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
15
0
15
0
% R
% Ser:
0
0
0
15
22
8
8
8
65
0
8
0
0
15
8
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
50
8
0
0
8
8
0
0
15
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
0
65
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _