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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMEM136 All Species: 36.97
Human Site: S68 Identified Species: 73.94
UniProt: Q6ZRR5 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6ZRR5 NP_777586.1 245 27841 S68 W P F T H P G S P N T P L Q V
Chimpanzee Pan troglodytes XP_508819 334 37017 S157 W P F T H P G S P N T P L Q V
Rhesus Macaque Macaca mulatta XP_001106879 245 27907 S68 W P F T H P G S P N T P L Q V
Dog Lupus familis XP_546478 245 27916 S68 W P F T H P G S P N T P L Q V
Cat Felis silvestris
Mouse Mus musculus Q3TYE7 245 27687 S68 W P F T H P G S P N T P L Q V
Rat Rattus norvegicus NP_001101606 245 27609 S68 W P F T H P G S P N T P L Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514279 312 34739 S135 W P F T H P G S P N T P L Q V
Chicken Gallus gallus XP_417891 244 27427 S67 W P L S H A G S P N T A L Q V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1LXV8 242 27287 T67 W P F T H P G T E N T Y F Q I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002325620 265 29872 Y88 L L L S G L F Y E D S R D E L
Maize Zea mays NP_001143039 259 27697 A85 C P V C P L A A A S S P R Q M
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_567355 266 30189 S96 H G D S V I N S T T R L S E S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 72.7 98.7 95 N.A. 92.2 91 N.A. 66.9 61.2 N.A. 56.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 73 99.5 96.7 N.A. 95.5 95.5 N.A. 71.4 73 N.A. 70.6 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 73.3 N.A. 66.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 80 N.A. 80 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 27.1 27 N.A. 26.3 N.A. N.A.
Protein Similarity: 43.4 44.7 N.A. 41.7 N.A. N.A.
P-Site Identity: 0 20 N.A. 6.6 N.A. N.A.
P-Site Similarity: 33.3 46.6 N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 9 9 9 9 0 0 9 0 0 0 % A
% Cys: 9 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 0 0 0 9 0 0 9 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 17 0 0 0 0 17 0 % E
% Phe: 0 0 67 0 0 0 9 0 0 0 0 0 9 0 0 % F
% Gly: 0 9 0 0 9 0 75 0 0 0 0 0 0 0 0 % G
% His: 9 0 0 0 75 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 9 17 0 0 17 0 0 0 0 0 9 67 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 0 0 9 0 0 75 0 0 0 0 0 % N
% Pro: 0 84 0 0 9 67 0 0 67 0 0 67 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 84 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 9 9 9 0 0 % R
% Ser: 0 0 0 25 0 0 0 75 0 9 17 0 9 0 9 % S
% Thr: 0 0 0 67 0 0 0 9 9 9 75 0 0 0 0 % T
% Val: 0 0 9 0 9 0 0 0 0 0 0 0 0 0 67 % V
% Trp: 75 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 9 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _