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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMEM136
All Species:
31.82
Human Site:
Y223
Identified Species:
63.64
UniProt:
Q6ZRR5
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZRR5
NP_777586.1
245
27841
Y223
W
R
K
S
I
K
K
Y
H
A
W
R
S
R
R
Chimpanzee
Pan troglodytes
XP_508819
334
37017
Y312
W
R
K
S
I
K
K
Y
H
A
W
R
S
R
R
Rhesus Macaque
Macaca mulatta
XP_001106879
245
27907
Y223
W
R
K
S
I
K
K
Y
H
A
W
R
S
R
R
Dog
Lupus familis
XP_546478
245
27916
Y223
W
R
K
S
I
K
K
Y
H
A
W
R
S
R
C
Cat
Felis silvestris
Mouse
Mus musculus
Q3TYE7
245
27687
Y223
W
K
K
S
I
K
K
Y
H
A
W
R
S
R
R
Rat
Rattus norvegicus
NP_001101606
245
27609
Y223
W
K
K
S
V
K
K
Y
H
A
W
R
S
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514279
312
34739
Y290
W
R
K
S
G
K
K
Y
R
A
W
R
S
G
R
Chicken
Gallus gallus
XP_417891
244
27427
Y222
R
R
K
M
L
K
K
Y
H
S
W
R
R
L
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q1LXV8
242
27287
Y222
C
R
K
T
C
G
K
Y
R
R
W
K
E
Q
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002325620
265
29872
V244
G
T
L
A
V
M
N
V
L
W
F
W
K
I
V
Maize
Zea mays
NP_001143039
259
27697
K240
Y
K
L
A
V
A
G
K
K
K
P
L
P
P
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_567355
266
30189
G250
W
F
W
K
I
T
K
G
L
I
K
T
L
S
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
72.7
98.7
95
N.A.
92.2
91
N.A.
66.9
61.2
N.A.
56.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
73
99.5
96.7
N.A.
95.5
95.5
N.A.
71.4
73
N.A.
70.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
86.6
N.A.
80
60
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
80
73.3
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
27.1
27
N.A.
26.3
N.A.
N.A.
Protein Similarity:
43.4
44.7
N.A.
41.7
N.A.
N.A.
P-Site Identity:
0
0
N.A.
20
N.A.
N.A.
P-Site Similarity:
20
26.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
0
9
0
0
0
59
0
0
0
0
0
% A
% Cys:
9
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
9
0
0
0
0
% F
% Gly:
9
0
0
0
9
9
9
9
0
0
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
59
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
50
0
0
0
0
9
0
0
0
9
0
% I
% Lys:
0
25
75
9
0
67
84
9
9
9
9
9
9
0
9
% K
% Leu:
0
0
17
0
9
0
0
0
17
0
0
9
9
9
0
% L
% Met:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
9
0
9
9
9
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% Q
% Arg:
9
59
0
0
0
0
0
0
17
9
0
67
9
50
59
% R
% Ser:
0
0
0
59
0
0
0
0
0
9
0
0
59
9
0
% S
% Thr:
0
9
0
9
0
9
0
0
0
0
0
9
0
0
0
% T
% Val:
0
0
0
0
25
0
0
9
0
0
0
0
0
0
9
% V
% Trp:
67
0
9
0
0
0
0
0
0
9
75
9
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
75
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _