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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHM3
All Species:
9.09
Human Site:
S461
Identified Species:
18.18
UniProt:
Q6ZWE6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZWE6
NP_001073944.1
761
87166
S461
A
A
N
V
A
R
S
S
E
Q
N
L
Q
V
T
Chimpanzee
Pan troglodytes
XP_001140597
761
87170
L461
A
A
N
V
A
R
S
L
E
Q
N
L
Q
V
T
Rhesus Macaque
Macaca mulatta
XP_001099880
587
66762
Q312
R
L
R
A
E
T
R
Q
R
A
Q
E
W
M
E
Dog
Lupus familis
XP_536046
773
88160
Y470
D
E
D
P
L
L
S
Y
N
V
D
V
C
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8BM47
761
86535
S461
A
A
N
A
A
R
S
S
E
Q
N
L
Q
V
T
Rat
Rattus norvegicus
Q5PQS0
1059
117490
E634
Q
K
V
R
P
Q
Q
E
E
E
W
V
N
I
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516425
584
64644
A309
L
W
A
G
A
R
G
A
G
P
A
Y
G
D
R
Chicken
Gallus gallus
XP_421947
759
86523
L459
A
A
N
V
T
R
S
L
G
Q
N
P
Q
V
T
Frog
Xenopus laevis
Q08AW4
748
85595
S448
A
A
N
S
A
R
K
S
D
Q
S
L
L
V
P
Zebra Danio
Brachydanio rerio
XP_001919480
711
80087
A434
R
E
K
K
H
K
E
A
Q
R
A
K
R
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VTT9
492
55389
V217
V
K
R
V
C
A
H
V
L
V
S
E
R
Q
H
Honey Bee
Apis mellifera
XP_395844
660
73853
D385
P
K
K
Q
Q
S
N
D
E
T
K
V
R
S
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
69.1
84.6
N.A.
91.8
25.3
N.A.
47.5
74.9
61.2
46.7
N.A.
22.7
23.7
N.A.
N.A.
Protein Similarity:
100
99.7
72.5
87.3
N.A.
94.4
40.2
N.A.
55.4
84.2
76.2
63.5
N.A.
38.3
44.6
N.A.
N.A.
P-Site Identity:
100
93.3
0
6.6
N.A.
93.3
6.6
N.A.
13.3
73.3
60
0
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
93.3
6.6
33.3
N.A.
93.3
33.3
N.A.
20
73.3
73.3
40
N.A.
20
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
42
42
9
17
42
9
0
17
0
9
17
0
0
0
9
% A
% Cys:
0
0
0
0
9
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
9
0
9
0
0
0
0
9
9
0
9
0
0
9
0
% D
% Glu:
0
17
0
0
9
0
9
9
42
9
0
17
0
0
17
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
9
0
0
9
0
17
0
0
0
9
0
0
% G
% His:
0
0
0
0
9
0
9
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% I
% Lys:
0
25
17
9
0
9
9
0
0
0
9
9
0
0
0
% K
% Leu:
9
9
0
0
9
9
0
17
9
0
0
34
9
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
42
0
0
0
9
0
9
0
34
0
9
0
0
% N
% Pro:
9
0
0
9
9
0
0
0
0
9
0
9
0
0
9
% P
% Gln:
9
0
0
9
9
9
9
9
9
42
9
0
34
17
9
% Q
% Arg:
17
0
17
9
0
50
9
0
9
9
0
0
25
0
9
% R
% Ser:
0
0
0
9
0
9
42
25
0
0
17
0
0
9
9
% S
% Thr:
0
0
0
0
9
9
0
0
0
9
0
0
0
0
34
% T
% Val:
9
0
9
34
0
0
0
9
0
17
0
25
0
42
0
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
9
0
9
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _