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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP53
All Species:
29.09
Human Site:
S445
Identified Species:
71.11
UniProt:
Q70EK8
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q70EK8
NP_061923.2
1073
120806
S445
R
E
K
I
K
D
I
S
R
E
C
A
L
K
A
Chimpanzee
Pan troglodytes
XP_517410
1073
120810
S445
R
E
K
I
K
D
I
S
R
E
C
A
L
K
A
Rhesus Macaque
Macaca mulatta
XP_001098826
1073
120920
S445
R
E
K
I
K
D
I
S
R
E
C
A
L
K
A
Dog
Lupus familis
XP_545046
1164
130992
S497
R
E
K
I
K
D
I
S
R
E
C
A
L
K
A
Cat
Felis silvestris
Mouse
Mus musculus
P15975
1069
119237
S443
R
E
K
I
K
D
I
S
R
E
C
A
L
K
A
Rat
Rattus norvegicus
Q6IE24
1588
176137
A471
L
A
S
Q
T
N
A
A
S
P
C
V
G
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512481
1110
122865
S444
K
D
K
I
K
D
I
S
R
E
C
A
Q
K
A
Chicken
Gallus gallus
XP_420633
1049
117873
S446
K
D
R
L
K
D
I
S
R
E
C
A
Q
K
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_570078
1746
191998
G523
Q
S
V
D
K
D
G
G
F
L
S
R
K
P
I
Honey Bee
Apis mellifera
XP_394511
1962
219527
T498
K
K
Q
Q
M
Q
L
T
R
S
L
S
A
G
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
96.2
77
N.A.
75
28.5
N.A.
62.2
56.4
N.A.
N.A.
N.A.
23.3
23.7
N.A.
N.A.
Protein Similarity:
100
99.5
98.2
82.9
N.A.
83
43.2
N.A.
72.9
67.9
N.A.
N.A.
N.A.
36.3
35.5
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
80
66.6
N.A.
N.A.
N.A.
13.3
6.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
20
53.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
10
10
0
0
0
70
10
0
80
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
80
0
0
0
0
% C
% Asp:
0
20
0
10
0
80
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
50
0
0
0
0
0
0
0
70
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
10
10
0
0
0
0
10
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
60
0
0
70
0
0
0
0
0
0
0
10
% I
% Lys:
30
10
60
0
80
0
0
0
0
0
0
0
10
70
0
% K
% Leu:
10
0
0
10
0
0
10
0
0
10
10
0
50
0
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% P
% Gln:
10
0
10
20
0
10
0
0
0
0
0
0
20
0
0
% Q
% Arg:
50
0
10
0
0
0
0
0
80
0
0
10
0
10
0
% R
% Ser:
0
10
10
0
0
0
0
70
10
10
10
10
0
0
10
% S
% Thr:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _