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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: USP45 All Species: 8.48
Human Site: S474 Identified Species: 14.36
UniProt: Q70EL2 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q70EL2 NP_001073950 814 91733 S474 G D S L M F A S L M N S E S R
Chimpanzee Pan troglodytes XP_001139771 814 91702 S474 G D S L M F A S L M N S E S R
Rhesus Macaque Macaca mulatta XP_001085248 815 91829 R475 G D S L M F A R L M N S E S P
Dog Lupus familis XP_539054 796 87704 S466 V N E P S W H S F P P E G A E
Cat Felis silvestris
Mouse Mus musculus Q8K387 813 90343 A473 N L E A S P P A S T L S T E A
Rat Rattus norvegicus Q2KJ09 826 93743 D478 T N Y T E D N D H E A E T A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506389 799 87920 R468 P A L L N P R R E T V G M N G
Chicken Gallus gallus O57429 357 40913 C28 L R N L G N T C F M N S I L Q
Frog Xenopus laevis Q6PAW2 901 101274 E479 E C S E D E E E V S Q T K T N
Zebra Danio Brachydanio rerio A8HAL1 815 90431 T485 A I T N Q S S T D P A D S S M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121285 844 94413 G488 E D N A E I E G L L P E V G E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_790411 1122 123641 S502 P V E E K K D S P I Q S D N E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FPT5 1083 120752 P579 R E G P V F R P L S K S E V Y
Baker's Yeast Sacchar. cerevisiae P50102 471 53605 G143 L S G L I N M G S T C F M S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.4 72.2 N.A. 77.4 38.7 N.A. 63.7 20.1 38.5 38 N.A. N.A. 29.3 N.A. 29.9
Protein Similarity: 100 99.7 96.6 81.5 N.A. 85.3 59.6 N.A. 75.5 29.7 56.4 56.6 N.A. N.A. 49.1 N.A. 45.3
P-Site Identity: 100 100 86.6 6.6 N.A. 6.6 0 N.A. 6.6 26.6 6.6 6.6 N.A. N.A. 13.3 N.A. 13.3
P-Site Similarity: 100 100 86.6 26.6 N.A. 13.3 13.3 N.A. 13.3 40 33.3 26.6 N.A. N.A. 26.6 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 20.3 20.7 N.A.
Protein Similarity: N.A. N.A. N.A. 37.6 35.5 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 15 0 0 22 8 0 0 15 0 0 15 8 % A
% Cys: 0 8 0 0 0 0 0 8 0 0 8 0 0 0 0 % C
% Asp: 0 29 0 0 8 8 8 8 8 0 0 8 8 0 0 % D
% Glu: 15 8 22 15 15 8 15 8 8 8 0 22 29 8 22 % E
% Phe: 0 0 0 0 0 29 0 0 15 0 0 8 0 0 0 % F
% Gly: 22 0 15 0 8 0 0 15 0 0 0 8 8 8 8 % G
% His: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 8 8 0 0 0 8 0 0 8 0 0 % I
% Lys: 0 0 0 0 8 8 0 0 0 0 8 0 8 0 0 % K
% Leu: 15 8 8 43 0 0 0 0 36 8 8 0 0 8 8 % L
% Met: 0 0 0 0 22 0 8 0 0 29 0 0 15 0 8 % M
% Asn: 8 15 15 8 8 15 8 0 0 0 29 0 0 15 8 % N
% Pro: 15 0 0 15 0 15 8 8 8 15 15 0 0 0 8 % P
% Gln: 0 0 0 0 8 0 0 0 0 0 15 0 0 0 8 % Q
% Arg: 8 8 0 0 0 0 15 15 0 0 0 0 0 0 15 % R
% Ser: 0 8 29 0 15 8 8 29 15 15 0 50 8 36 8 % S
% Thr: 8 0 8 8 0 0 8 8 0 22 0 8 15 8 0 % T
% Val: 8 8 0 0 8 0 0 0 8 0 8 0 8 8 0 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _