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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FRA10AC1 All Species: 47.27
Human Site: S188 Identified Species: 69.33
UniProt: Q70Z53 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q70Z53 NP_660289.2 315 37584 S188 D K K E G L K S W E V N F G Y
Chimpanzee Pan troglodytes XP_507931 315 37511 S188 D K K E G L K S W E V N F G Y
Rhesus Macaque Macaca mulatta XP_001092952 315 37404 S188 D K K E G L K S W E V N F G Y
Dog Lupus familis XP_534970 399 47063 S274 D K K E D L K S W E V N F G Y
Cat Felis silvestris
Mouse Mus musculus Q8BP78 315 37243 S188 N E K E G L R S W E V N F G Y
Rat Rattus norvegicus Q5FVF1 315 37100 S188 D E K E G L K S W E V N F G Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507589 346 40793 S221 E A K E G L K S W E V N F G Y
Chicken Gallus gallus XP_421674 329 38511 S198 D G E E G L K S W E V N F G Y
Frog Xenopus laevis NP_001086932 322 38377 S192 D E K E G L K S W E V N F G Y
Zebra Danio Brachydanio rerio NP_001006006 333 39156 S197 E S K E G L K S W E V N F A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001122241 200 24077 E79 Y Y D K L F K E Y C I A D L T
Nematode Worm Caenorhab. elegans NP_001129806 316 37238 L195 K C N E T A H L S S W E V N F
Sea Urchin Strong. purpuratus XP_782837 350 41331 T187 A E Q E G L R T W E V N F A Y
Poplar Tree Populus trichocarpa XP_002299940 243 28747 I122 W R T E K E V I S G K G Q F I
Maize Zea mays NP_001144502 172 20429 V51 F Y G H E K N V D S S L P I K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001154235 282 33712 S147 D E K E G L A S Y E V N F S Y
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.7 71.6 N.A. 86 86.9 N.A. 65.6 68.3 65.5 65.1 N.A. N.A. 41.9 39.5 48.2
Protein Similarity: 100 99.6 98 74.6 N.A. 93.6 94.2 N.A. 76.8 78.4 78.2 75.6 N.A. N.A. 50.1 57.9 64
P-Site Identity: 100 100 100 93.3 N.A. 80 93.3 N.A. 86.6 86.6 93.3 80 N.A. N.A. 6.6 6.6 60
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 93.3 93.3 100 86.6 N.A. N.A. 26.6 13.3 86.6
Percent
Protein Identity: 39.6 32 N.A. 39.6 N.A. N.A.
Protein Similarity: 54.2 41.5 N.A. 54.6 N.A. N.A.
P-Site Identity: 6.6 0 N.A. 73.3 N.A. N.A.
P-Site Similarity: 13.3 0 N.A. 86.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 0 0 7 7 0 0 0 0 7 0 13 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 50 0 7 0 7 0 0 0 7 0 0 0 7 0 0 % D
% Glu: 13 32 7 88 7 7 0 7 0 75 0 7 0 0 0 % E
% Phe: 7 0 0 0 0 7 0 0 0 0 0 0 75 7 7 % F
% Gly: 0 7 7 0 69 0 0 0 0 7 0 7 0 57 0 % G
% His: 0 0 0 7 0 0 7 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 7 0 0 7 0 0 7 7 % I
% Lys: 7 25 63 7 7 7 63 0 0 0 7 0 0 0 7 % K
% Leu: 0 0 0 0 7 75 0 7 0 0 0 7 0 7 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 7 0 0 0 7 0 0 0 0 75 0 7 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 0 0 7 0 0 % Q
% Arg: 0 7 0 0 0 0 13 0 0 0 0 0 0 0 0 % R
% Ser: 0 7 0 0 0 0 0 69 13 13 7 0 0 7 0 % S
% Thr: 0 0 7 0 7 0 0 7 0 0 0 0 0 0 7 % T
% Val: 0 0 0 0 0 0 7 7 0 0 75 0 7 0 0 % V
% Trp: 7 0 0 0 0 0 0 0 69 0 7 0 0 0 0 % W
% Tyr: 7 13 0 0 0 0 0 0 13 0 0 0 0 0 75 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _