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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED25
All Species:
13.33
Human Site:
T166
Identified Species:
32.59
UniProt:
Q71SY5
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q71SY5
NP_112235.2
747
78171
T166
T
T
Y
S
G
C
T
T
E
N
L
V
Q
Q
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001115505
747
78242
T166
T
T
Y
S
G
C
T
T
E
N
L
V
Q
Q
I
Dog
Lupus familis
XP_541489
728
76293
T166
T
T
Y
S
G
Y
T
T
E
S
L
V
Q
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCB2
745
78094
T166
T
T
Y
S
G
C
T
T
E
S
L
V
Q
K
I
Rat
Rattus norvegicus
Q5U2W6
416
46830
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518479
472
49735
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6GP15
801
86494
R172
L
V
Q
K
I
G
E
R
G
I
H
F
S
I
I
Zebra Danio
Brachydanio rerio
Q6PEH8
701
75444
A163
V
S
Y
T
G
C
T
A
D
S
L
V
Q
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VDR1
863
96623
N170
E
Q
L
A
A
L
F
N
E
R
K
I
N
L
S
Honey Bee
Apis mellifera
XP_395016
915
100283
I180
Y
K
F
A
G
H
T
I
E
Q
L
A
T
L
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.1
94.3
N.A.
92.7
26.1
N.A.
47.1
N.A.
64.7
57
N.A.
27.5
29.6
N.A.
N.A.
Protein Similarity:
100
N.A.
99.3
95.3
N.A.
93.9
35
N.A.
50.7
N.A.
71.2
66
N.A.
40.5
42.6
N.A.
N.A.
P-Site Identity:
100
N.A.
100
80
N.A.
86.6
0
N.A.
0
N.A.
6.6
53.3
N.A.
6.6
26.6
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
93.3
N.A.
100
0
N.A.
0
N.A.
6.6
80
N.A.
20
40
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
10
0
0
10
0
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
40
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% D
% Glu:
10
0
0
0
0
0
10
0
60
0
0
0
0
0
0
% E
% Phe:
0
0
10
0
0
0
10
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
0
0
60
10
0
0
10
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
10
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
10
0
10
0
10
0
20
60
% I
% Lys:
0
10
0
10
0
0
0
0
0
0
10
0
0
20
0
% K
% Leu:
10
0
10
0
0
10
0
0
0
0
60
0
0
20
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
0
20
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
10
0
0
0
0
0
0
10
0
0
50
20
0
% Q
% Arg:
0
0
0
0
0
0
0
10
0
10
0
0
0
0
0
% R
% Ser:
0
10
0
40
0
0
0
0
0
30
0
0
10
0
10
% S
% Thr:
40
40
0
10
0
0
60
40
0
0
0
0
10
0
0
% T
% Val:
10
10
0
0
0
0
0
0
0
0
0
50
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
50
0
0
10
0
0
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _