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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERN2 All Species: 7.88
Human Site: S8 Identified Species: 19.26
UniProt: Q76MJ5 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q76MJ5 NP_150296.3 926 102466 S8 M A S A V R G S R P W P R L G
Chimpanzee Pan troglodytes XP_510880 974 107065 S56 M A S A V R G S R P W P R L G
Rhesus Macaque Macaca mulatta XP_001089227 820 89327
Dog Lupus familis XP_547090 925 102471 P8 M V C G P W P P L R L G L L L
Cat Felis silvestris
Mouse Mus musculus Q9Z2E3 911 101337 F8 M A R P V Q R F Q L W S P L G
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505283 1129 123221 G8 M T S T E D S G K P G S L D A
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392044 968 110555 I8 M R F K L V L I F L T I K L F
Nematode Worm Caenorhab. elegans Q09499 967 109804 T9 R A T F H L F T F I F L L L F
Sea Urchin Strong. purpuratus XP_786178 1112 123199 M12 I I M N E F G M I L F I F L V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32361 1115 126957 S29 I S C S I P L S S R T S R R Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.2 77.6 84.2 N.A. 80.5 N.A. N.A. 53.5 N.A. N.A. N.A. N.A. N.A. 38.4 37.4 36
Protein Similarity: 100 94.4 79.5 88.9 N.A. 86.2 N.A. N.A. 61.8 N.A. N.A. N.A. N.A. N.A. 54.3 54.5 48.2
P-Site Identity: 100 100 0 13.3 N.A. 40 N.A. N.A. 20 N.A. N.A. N.A. N.A. N.A. 13.3 13.3 13.3
P-Site Similarity: 100 100 0 13.3 N.A. 53.3 N.A. N.A. 26.6 N.A. N.A. N.A. N.A. N.A. 26.6 33.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 40 0 20 0 0 0 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 20 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 0 % D
% Glu: 0 0 0 0 20 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 10 10 0 10 10 10 20 0 20 0 10 0 20 % F
% Gly: 0 0 0 10 0 0 30 10 0 0 10 10 0 0 30 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 20 10 0 0 10 0 0 10 10 10 0 20 0 0 0 % I
% Lys: 0 0 0 10 0 0 0 0 10 0 0 0 10 0 0 % K
% Leu: 0 0 0 0 10 10 20 0 10 30 10 10 30 70 10 % L
% Met: 60 0 10 0 0 0 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 10 10 10 10 10 0 30 0 20 10 0 0 % P
% Gln: 0 0 0 0 0 10 0 0 10 0 0 0 0 0 10 % Q
% Arg: 10 10 10 0 0 20 10 0 20 20 0 0 30 10 0 % R
% Ser: 0 10 30 10 0 0 10 30 10 0 0 30 0 0 0 % S
% Thr: 0 10 10 10 0 0 0 10 0 0 20 0 0 0 0 % T
% Val: 0 10 0 0 30 10 0 0 0 0 0 0 0 0 10 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 30 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _