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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK2
All Species:
13.64
Human Site:
T450
Identified Species:
25
UniProt:
Q7KZI7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7KZI7
NP_001034558.2
788
87911
T450
S
G
R
K
A
S
S
T
A
K
V
P
A
S
P
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
V457
K
E
E
W
D
K
D
V
A
R
K
L
G
S
T
Rhesus Macaque
Macaca mulatta
XP_001115591
788
87964
T450
S
G
R
K
A
S
S
T
A
K
V
P
A
S
P
Dog
Lupus familis
XP_540890
798
88683
T469
S
G
R
K
A
S
S
T
A
K
V
P
A
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q05512
776
86287
T447
T
G
R
K
A
S
S
T
A
K
V
P
A
S
P
Rat
Rattus norvegicus
O08679
722
80853
R397
S
P
S
H
K
V
Q
R
S
V
S
A
N
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
V456
K
E
E
W
D
K
D
V
S
R
K
L
S
S
T
Chicken
Gallus gallus
Q9IA88
798
88848
K451
S
E
E
V
R
Q
E
K
E
L
E
D
E
I
K
Frog
Xenopus laevis
NP_001080425
785
87931
V454
G
R
K
S
S
S
T
V
R
V
P
P
S
P
L
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
Q545
A
N
I
Q
L
H
T
Q
Q
L
L
K
R
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
Q567
A
A
N
A
Q
K
H
Q
Q
S
S
A
A
P
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
P186
G
S
P
N
Y
A
A
P
E
V
I
S
G
K
L
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
V308
M
Q
D
D
W
F
K
V
D
L
P
E
Y
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.2
99.7
95.1
N.A.
96.6
89.9
N.A.
68.4
30.3
84.3
27.5
N.A.
N.A.
N.A.
38.8
N.A.
Protein Similarity:
100
80.4
99.7
96.2
N.A.
97.7
90.9
N.A.
80.5
48.7
91.7
42.7
N.A.
N.A.
N.A.
49.9
N.A.
P-Site Identity:
100
13.3
100
100
N.A.
93.3
6.6
N.A.
6.6
6.6
13.3
0
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
13.3
N.A.
26.6
6.6
40
26.6
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.5
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.1
45.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
8
31
8
8
0
39
0
0
16
39
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
16
0
16
0
8
0
0
8
0
0
0
% D
% Glu:
0
24
24
0
0
0
8
0
16
0
8
8
8
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
16
31
0
0
0
0
0
0
0
0
0
0
16
0
0
% G
% His:
0
0
0
8
0
8
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
8
0
0
8
0
% I
% Lys:
16
0
8
31
8
24
8
8
0
31
16
8
0
8
16
% K
% Leu:
0
0
0
0
8
0
0
0
0
24
8
16
0
8
24
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
0
8
8
0
0
0
0
8
0
0
16
39
0
31
31
% P
% Gln:
0
8
0
8
8
8
8
16
16
0
0
0
0
0
0
% Q
% Arg:
0
8
31
0
8
0
0
8
8
16
0
0
8
0
8
% R
% Ser:
39
8
8
8
8
39
31
0
16
8
16
8
16
47
8
% S
% Thr:
8
0
0
0
0
0
16
31
0
0
0
0
0
0
16
% T
% Val:
0
0
0
8
0
8
0
31
0
24
31
0
0
0
0
% V
% Trp:
0
0
0
16
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _