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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK2
All Species:
35.76
Human Site:
Y226
Identified Species:
65.56
UniProt:
Q7KZI7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7KZI7
NP_001034558.2
788
87911
Y226
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
Y233
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
Rhesus Macaque
Macaca mulatta
XP_001115591
788
87964
Y226
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
Dog
Lupus familis
XP_540890
798
88683
Y246
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q05512
776
86287
I226
E
L
F
Q
G
K
K
I
D
G
P
E
V
D
V
Rat
Rattus norvegicus
O08679
722
80853
A185
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
Y232
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
Chicken
Gallus gallus
Q9IA88
798
88848
Y199
E
V
F
E
G
K
E
Y
E
G
P
H
L
D
I
Frog
Xenopus laevis
NP_001080425
785
87931
Y230
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
Y232
E
L
F
E
G
K
E
Y
D
G
P
K
V
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
Y343
E
L
F
S
G
K
K
Y
D
G
P
E
V
D
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
M96
K
V
L
A
K
S
D
M
Q
G
R
I
E
R
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.2
99.7
95.1
N.A.
96.6
89.9
N.A.
68.4
30.3
84.3
27.5
N.A.
N.A.
N.A.
38.8
N.A.
Protein Similarity:
100
80.4
99.7
96.2
N.A.
97.7
90.9
N.A.
80.5
48.7
91.7
42.7
N.A.
N.A.
N.A.
49.9
N.A.
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
100
53.3
100
73.3
N.A.
N.A.
N.A.
93.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
93.3
6.6
N.A.
100
93.3
100
100
N.A.
N.A.
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.5
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.1
45.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
0
0
8
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
16
0
77
0
0
0
0
77
0
% D
% Glu:
77
8
0
16
0
0
16
0
8
0
0
62
8
0
8
% E
% Phe:
0
0
77
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
77
0
0
0
0
85
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
16
0
8
16
% I
% Lys:
8
0
0
0
8
77
62
0
0
0
0
8
8
0
0
% K
% Leu:
0
70
8
8
8
8
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
77
0
0
0
0
% P
% Gln:
0
0
0
54
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% R
% Ser:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
16
0
0
0
0
0
0
0
0
0
0
70
0
62
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _