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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MARK2 All Species: 10.61
Human Site: Y363 Identified Species: 19.44
UniProt: Q7KZI7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7KZI7 NP_001034558.2 788 87911 Y363 A T Y L L L G Y K S S E L E G
Chimpanzee Pan troglodytes XP_001172839 796 89049 R370 A T Y I L L G R K P P E F E V
Rhesus Macaque Macaca mulatta XP_001115591 788 87964 Y363 A T Y L L L G Y K S S E L E G
Dog Lupus familis XP_540890 798 88683 G382 M A T Y L L L G Y K S S E L E
Cat Felis silvestris
Mouse Mus musculus Q05512 776 86287 L360 E V M A T Y L L L G Y K S S E
Rat Rattus norvegicus O08679 722 80853 D310 W M N V G H E D D E L K P Y V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511751 793 88836 R369 A T Y L L L G R K P P E F E G
Chicken Gallus gallus Q9IA88 798 88848 P364 A T G R Q Q R P R S S E I S N
Frog Xenopus laevis NP_001080425 785 87931 Y367 A T Y L L L G Y R T S E M D N
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 D458 R H T V G V P D P R A E M Q E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 L480 D I H A T Y L L L G E R K S D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 Y99 D I Y V V M E Y V K S G E L F
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 E221 S P N Y A A P E V I S G K L Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 68.2 99.7 95.1 N.A. 96.6 89.9 N.A. 68.4 30.3 84.3 27.5 N.A. N.A. N.A. 38.8 N.A.
Protein Similarity: 100 80.4 99.7 96.2 N.A. 97.7 90.9 N.A. 80.5 48.7 91.7 42.7 N.A. N.A. N.A. 49.9 N.A.
P-Site Identity: 100 60 100 20 N.A. 0 0 N.A. 73.3 33.3 66.6 6.6 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 66.6 100 20 N.A. 6.6 13.3 N.A. 73.3 46.6 93.3 40 N.A. N.A. N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.5 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. 44.1 45.5 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 47 8 0 16 8 8 0 0 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 0 0 0 0 0 0 16 8 0 0 0 0 8 8 % D
% Glu: 8 0 0 0 0 0 16 8 0 8 8 54 16 31 24 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 16 0 8 % F
% Gly: 0 0 8 0 16 0 39 8 0 16 0 16 0 0 24 % G
% His: 0 8 8 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 16 0 8 0 0 0 0 0 8 0 0 8 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 31 16 0 16 16 0 0 % K
% Leu: 0 0 0 31 47 47 24 16 16 0 8 0 16 24 0 % L
% Met: 8 8 8 0 0 8 0 0 0 0 0 0 16 0 0 % M
% Asn: 0 0 16 0 0 0 0 0 0 0 0 0 0 0 16 % N
% Pro: 0 8 0 0 0 0 16 8 8 16 16 0 8 0 0 % P
% Gln: 0 0 0 0 8 8 0 0 0 0 0 0 0 8 0 % Q
% Arg: 8 0 0 8 0 0 8 16 16 8 0 8 0 0 0 % R
% Ser: 8 0 0 0 0 0 0 0 0 24 54 8 8 24 0 % S
% Thr: 0 47 16 0 16 0 0 0 0 8 0 0 0 0 0 % T
% Val: 0 8 0 24 8 8 0 0 16 0 0 0 0 0 16 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 47 16 0 16 0 31 8 0 8 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _