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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX46 All Species: 22.73
Human Site: S105 Identified Species: 31.25
UniProt: Q7L014 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.19
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7L014 NP_055644.2 1031 117362 S105 R G R R S R S S S P G N K S K
Chimpanzee Pan troglodytes XP_517939 1173 133261 S247 R G R R S R S S S P G N K S K
Rhesus Macaque Macaca mulatta XP_001109331 1031 117356 S105 R G R R S R S S S P G N K S K
Dog Lupus familis XP_531911 1031 117344 S105 R G R R S R S S S P G N K S K
Cat Felis silvestris
Mouse Mus musculus Q569Z5 1032 117430 S105 R G R R S R S S S P G S K T K
Rat Rattus norvegicus Q62780 1032 117367 S105 R G R R S R S S S P G S K S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510706 974 110456 R106 L E E E M R K R K E R V E K W
Chicken Gallus gallus Q5F485 944 103035 K105 T R Q Q F N S K S A D S D S D
Frog Xenopus laevis Q7ZY47 947 104061 D106 L R S K T D S D S E E D P L E
Zebra Danio Brachydanio rerio Q4TVV3 1018 115121 I105 Q T A D K K K I K E E K E E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573020 1224 136263 D142 K E R E R D K D R E R D R Q R
Honey Bee Apis mellifera XP_001122722 1018 114528 R108 N R S R S R E R K E K E K G D
Nematode Worm Caenorhab. elegans NP_001033411 970 109887 R107 Q G V E R R R R N V E K W R A
Sea Urchin Strong. purpuratus XP_784902 869 99209 R77 S R S R S R D R D R R R S P P
Poplar Tree Populus trichocarpa XP_002301895 1112 128539 E131 R D R D K D R E E K R E R A K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H0U8 1166 133015 K119 D K R R V N E K E R G H R E H
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SH33 1194 131283 P115 R R D R S R D P D R E Y R P R
Conservation
Percent
Protein Identity: 100 87.8 99.9 99.8 N.A. 98.8 98.6 N.A. 89.6 29.7 30.2 83 N.A. 49.6 63.8 47.8 54.5
Protein Similarity: 100 87.8 99.9 99.8 N.A. 99.5 99.3 N.A. 92.5 45.7 48.2 90.1 N.A. 62.9 75.9 65.9 65.8
P-Site Identity: 100 100 100 100 N.A. 86.6 93.3 N.A. 6.6 20 13.3 0 N.A. 6.6 26.6 13.3 20
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 40 40 26.6 N.A. 33.3 26.6 26.6 20
Percent
Protein Identity: 43.9 N.A. N.A. 43.3 N.A. 41.3
Protein Similarity: 60.1 N.A. N.A. 58.5 N.A. 56.2
P-Site Identity: 20 N.A. N.A. 20 N.A. 26.6
P-Site Similarity: 33.3 N.A. N.A. 33.3 N.A. 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 0 0 0 0 0 0 6 0 0 0 6 6 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 6 6 6 12 0 18 12 12 12 0 6 12 6 0 12 % D
% Glu: 0 12 6 18 0 0 12 6 12 30 24 12 12 12 12 % E
% Phe: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 42 0 0 0 0 0 0 0 0 42 0 0 6 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 6 % H
% Ile: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % I
% Lys: 6 6 0 6 12 6 18 12 18 6 6 12 42 6 42 % K
% Leu: 12 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % L
% Met: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 6 0 0 0 0 12 0 0 6 0 0 24 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 6 0 36 0 0 6 12 6 % P
% Gln: 12 0 6 6 0 0 0 0 0 0 0 0 0 6 0 % Q
% Arg: 48 30 53 59 12 65 12 24 6 18 24 6 24 6 12 % R
% Ser: 6 0 18 0 53 0 48 36 48 0 0 18 6 36 0 % S
% Thr: 6 6 0 0 6 0 0 0 0 0 0 0 0 6 0 % T
% Val: 0 0 6 0 6 0 0 0 0 6 0 6 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 6 0 6 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _