Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DDX46 All Species: 23.33
Human Site: S111 Identified Species: 32.08
UniProt: Q7L014 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7L014 NP_055644.2 1031 117362 S111 S S S P G N K S K K T E N R S
Chimpanzee Pan troglodytes XP_517939 1173 133261 S253 S S S P G N K S K K T E N R S
Rhesus Macaque Macaca mulatta XP_001109331 1031 117356 S111 S S S P G N K S K K I E N R S
Dog Lupus familis XP_531911 1031 117344 S111 S S S P G N K S K K A E N R S
Cat Felis silvestris
Mouse Mus musculus Q569Z5 1032 117430 T111 S S S P G S K T K K T E N R S
Rat Rattus norvegicus Q62780 1032 117367 S111 S S S P G S K S K K A E N R S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510706 974 110456 K112 K R K E R V E K W R E E Q R K
Chicken Gallus gallus Q5F485 944 103035 S111 S K S A D S D S D D D P L E A
Frog Xenopus laevis Q7ZY47 947 104061 L112 S D S E E D P L E A F M A E V
Zebra Danio Brachydanio rerio Q4TVV3 1018 115121 E111 K I K E E K E E E K P E D Q D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573020 1224 136263 Q148 K D R E R D R Q R E K E S D S
Honey Bee Apis mellifera XP_001122722 1018 114528 G114 E R K E K E K G D S D E L P F
Nematode Worm Caenorhab. elegans NP_001033411 970 109887 R113 R R N V E K W R A Q K K K E E
Sea Urchin Strong. purpuratus XP_784902 869 99209 P83 D R D R R R S P P R R D R D I
Poplar Tree Populus trichocarpa XP_002301895 1112 128539 A137 R E E K R E R A K E K E K D R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8H0U8 1166 133015 E125 E K E R G H R E H E R D R G K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SH33 1194 131283 P121 D P D R E Y R P R R D D S R D
Conservation
Percent
Protein Identity: 100 87.8 99.9 99.8 N.A. 98.8 98.6 N.A. 89.6 29.7 30.2 83 N.A. 49.6 63.8 47.8 54.5
Protein Similarity: 100 87.8 99.9 99.8 N.A. 99.5 99.3 N.A. 92.5 45.7 48.2 90.1 N.A. 62.9 75.9 65.9 65.8
P-Site Identity: 100 100 93.3 93.3 N.A. 86.6 86.6 N.A. 13.3 20 13.3 13.3 N.A. 13.3 13.3 0 0
P-Site Similarity: 100 100 93.3 93.3 N.A. 100 93.3 N.A. 26.6 33.3 26.6 40 N.A. 46.6 13.3 20 13.3
Percent
Protein Identity: 43.9 N.A. N.A. 43.3 N.A. 41.3
Protein Similarity: 60.1 N.A. N.A. 58.5 N.A. 56.2
P-Site Identity: 13.3 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 33.3 N.A. N.A. 33.3 N.A. 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 6 0 0 0 6 6 6 12 0 6 0 6 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 12 12 0 6 12 6 0 12 6 18 18 6 18 12 % D
% Glu: 12 6 12 30 24 12 12 12 12 18 6 65 0 18 6 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 6 % F
% Gly: 0 0 0 0 42 0 0 6 0 0 0 0 0 6 0 % G
% His: 0 0 0 0 0 6 0 0 6 0 0 0 0 0 0 % H
% Ile: 0 6 0 0 0 0 0 0 0 0 6 0 0 0 6 % I
% Lys: 18 12 18 6 6 12 42 6 42 42 18 6 12 0 12 % K
% Leu: 0 0 0 0 0 0 0 6 0 0 0 0 12 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % M
% Asn: 0 0 6 0 0 24 0 0 0 0 0 0 36 0 0 % N
% Pro: 0 6 0 36 0 0 6 12 6 0 6 6 0 6 0 % P
% Gln: 0 0 0 0 0 0 0 6 0 6 0 0 6 6 0 % Q
% Arg: 12 24 6 18 24 6 24 6 12 18 12 0 12 48 6 % R
% Ser: 48 36 48 0 0 18 6 36 0 6 0 0 12 0 42 % S
% Thr: 0 0 0 0 0 0 0 6 0 0 18 0 0 0 0 % T
% Val: 0 0 0 6 0 6 0 0 0 0 0 0 0 0 6 % V
% Trp: 0 0 0 0 0 0 6 0 6 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _