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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM10 All Species: 9.09
Human Site: Y641 Identified Species: 16.67
UniProt: Q7L590 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7L590 NP_060988.3 875 98183 Y641 E G D D V L F Y D E S P P P R
Chimpanzee Pan troglodytes XP_001140870 874 98112 Y640 E G D D V L F Y D E S P P P R
Rhesus Macaque Macaca mulatta XP_001085751 873 97875 Y640 E G D D V L F Y D E S P P P R
Dog Lupus familis XP_544256 875 97644 F641 E G D D V L F F D E S P P P R
Cat Felis silvestris
Mouse Mus musculus Q0VBD2 885 98387 F653 E G D D V L F F D D S P P P R
Rat Rattus norvegicus NP_001100836 889 98964 F657 D G D D V L F F D E S P P P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423055 729 81488 I521 R L R A K G H I L D K T D P N
Frog Xenopus laevis Q5EAW4 860 95399 F627 E G D D V L F F D I S P P P A
Zebra Danio Brachydanio rerio Q5RHY1 833 92421 V619 S A T K L A A V R K L Q A K G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VIE6 776 86505 K568 L K A A A L L K K K P L E K I
Honey Bee Apis mellifera XP_001121461 641 73638 V433 K R N A V N W V K E N G K I K
Nematode Worm Caenorhab. elegans NP_499456 691 76034 A483 M S L A N K K A A P L G H K D
Sea Urchin Strong. purpuratus XP_782384 703 78261 I495 V I H K K G G I A K E D P N A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 94.6 83.1 N.A. 74.6 76.8 N.A. N.A. 53.5 58 45.9 N.A. 28.6 27.2 25 29.3
Protein Similarity: 100 99.5 97.4 90.7 N.A. 84.7 86.1 N.A. N.A. 66.1 72.8 62.9 N.A. 47.4 44.4 42.6 45.2
P-Site Identity: 100 100 100 93.3 N.A. 86.6 80 N.A. N.A. 6.6 80 0 N.A. 6.6 13.3 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 13.3 86.6 13.3 N.A. 13.3 46.6 0 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 31 8 8 8 8 16 0 0 0 8 0 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 54 54 0 0 0 0 54 16 0 8 8 0 8 % D
% Glu: 47 0 0 0 0 0 0 0 0 47 8 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 54 31 0 0 0 0 0 0 0 % F
% Gly: 0 54 0 0 0 16 8 0 0 0 0 16 0 0 8 % G
% His: 0 0 8 0 0 0 8 0 0 0 0 0 8 0 0 % H
% Ile: 0 8 0 0 0 0 0 16 0 8 0 0 0 8 8 % I
% Lys: 8 8 0 16 16 8 8 8 16 24 8 0 8 24 16 % K
% Leu: 8 8 8 0 8 62 8 0 8 0 16 8 0 0 0 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 8 8 0 0 0 0 8 0 0 8 8 % N
% Pro: 0 0 0 0 0 0 0 0 0 8 8 54 62 62 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 8 8 8 0 0 0 0 0 8 0 0 0 0 0 39 % R
% Ser: 8 8 0 0 0 0 0 0 0 0 54 0 0 0 0 % S
% Thr: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % T
% Val: 8 0 0 0 62 0 0 16 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 24 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _