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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RRM2B All Species: 33.64
Human Site: S72 Identified Species: 56.92
UniProt: Q7LG56 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7LG56 NP_056528.2 351 40737 S72 T A E E V D L S K D L P H W N
Chimpanzee Pan troglodytes XP_001153859 297 34470 S36 A D E K Y F I S H I L A F F A
Rhesus Macaque Macaca mulatta XP_001099964 297 34498 S36 A D E K Y F I S H I L A F F A
Dog Lupus familis XP_539109 351 40882 S72 T A E E V D L S K D L P H W N
Cat Felis silvestris
Mouse Mus musculus Q6PEE3 351 40785 S72 T A E E V D L S K D L P H W N
Rat Rattus norvegicus Q4KLN6 390 45020 S111 T A E E V D L S K D I Q H W E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508783 401 45907 S122 T A E E V D L S K D L P H W N
Chicken Gallus gallus XP_418364 353 40764 S74 T A E E V D L S K D L P H W N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio P79733 386 44575 S107 T A E E V D L S K D L Q H W D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48592 393 45096 S114 T V E E V D L S K D L T D W H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P42170 381 44271 G102 T V E E V D L G K D M N D W E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q6Y657 333 38312 H63 S L T N D E R H F I K H V L A
Baker's Yeast Sacchar. cerevisiae P09938 399 46129 K117 A E E I D L S K D I H D W N N
Red Bread Mold Neurospora crassa Q9C167 410 46679 K118 A E E I D L S K D L H D W N N
Conservation
Percent
Protein Identity: 100 84.6 83.7 95.7 N.A. 93.4 70.2 N.A. 79 87.5 N.A. 71.5 N.A. 67.1 N.A. 61.6 N.A.
Protein Similarity: 100 84.6 84.6 98.5 N.A. 97.4 82 N.A. 84.7 92.6 N.A. 81.8 N.A. 77.6 N.A. 76.1 N.A.
P-Site Identity: 100 20 20 100 N.A. 100 80 N.A. 100 100 N.A. 86.6 N.A. 73.3 N.A. 60 N.A.
P-Site Similarity: 100 40 40 100 N.A. 100 86.6 N.A. 100 100 N.A. 93.3 N.A. 80 N.A. 66.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 61.8 56.8 61.2
Protein Similarity: N.A. N.A. N.A. 74.6 73.1 74.3
P-Site Identity: N.A. N.A. N.A. 0 13.3 13.3
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 29 50 0 0 0 0 0 0 0 0 0 15 0 0 22 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 15 0 0 22 65 0 0 15 65 0 15 15 0 8 % D
% Glu: 0 15 93 65 0 8 0 0 0 0 0 0 0 0 15 % E
% Phe: 0 0 0 0 0 15 0 0 8 0 0 0 15 15 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 8 15 0 15 8 50 0 8 % H
% Ile: 0 0 0 15 0 0 15 0 0 29 8 0 0 0 0 % I
% Lys: 0 0 0 15 0 0 0 15 65 0 8 0 0 0 0 % K
% Leu: 0 8 0 0 0 15 65 0 0 8 65 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 0 8 0 15 50 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 36 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % Q
% Arg: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % R
% Ser: 8 0 0 0 0 0 15 72 0 0 0 0 0 0 0 % S
% Thr: 65 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % T
% Val: 0 15 0 0 65 0 0 0 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 15 65 0 % W
% Tyr: 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _