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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: OTOP3 All Species: 13.94
Human Site: S516 Identified Species: 30.67
UniProt: Q7RTS5 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7RTS5 NP_839947.1 596 66296 S516 A S L A Y I H S Y S H L N W K
Chimpanzee Pan troglodytes XP_511667 562 62246 S482 R E A V A I V S T P G S Q W R
Rhesus Macaque Macaca mulatta XP_001097009 610 67161 R530 P S P V R L P R F L Q G N A K
Dog Lupus familis XP_540423 578 64532 S498 A S L A Y I H S Y S H L N W K
Cat Felis silvestris
Mouse Mus musculus Q80UF9 577 64725 S497 A S R A Y I H S F S H L N W K
Rat Rattus norvegicus Q7M734 600 65910 D520 T G T T R C L D F L Q G G M K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512756 366 39394 A296 A N P V A P L A L S P S P V S
Chicken Gallus gallus XP_420115 559 63424 T479 V S L S Y I H T Y S H L G W K
Frog Xenopus laevis NP_001079194 408 46768 C337 I S F L M Y Y C Y K V I I L P
Zebra Danio Brachydanio rerio Q7ZWK8 586 65703 L506 P L P A G Q R L D V T P G R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_394346 560 61872 W467 T L L I K I A W G R R C S R N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 41.2 33.4 83 N.A. 79.1 33.3 N.A. 27.1 57.8 24.5 31.2 N.A. N.A. 21.1 N.A. N.A.
Protein Similarity: 100 57 49 88.2 N.A. 86 49 N.A. 37 74.3 40.9 49.1 N.A. N.A. 38.4 N.A. N.A.
P-Site Identity: 100 20 20 100 N.A. 86.6 6.6 N.A. 13.3 73.3 13.3 13.3 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 100 26.6 33.3 100 N.A. 93.3 13.3 N.A. 26.6 86.6 26.6 13.3 N.A. N.A. 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 37 0 10 37 19 0 10 10 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 10 0 10 0 0 0 10 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 10 10 0 0 0 0 0 0 % D
% Glu: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 28 0 0 0 0 0 0 % F
% Gly: 0 10 0 0 10 0 0 0 10 0 10 19 28 0 0 % G
% His: 0 0 0 0 0 0 37 0 0 0 37 0 0 0 0 % H
% Ile: 10 0 0 10 0 55 0 0 0 0 0 10 10 0 0 % I
% Lys: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 64 % K
% Leu: 0 19 37 10 0 10 19 10 10 19 0 37 0 10 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 10 0 0 0 0 0 0 0 0 0 0 37 0 10 % N
% Pro: 19 0 28 0 0 10 10 0 0 10 10 10 10 0 10 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 19 0 10 0 0 % Q
% Arg: 10 0 10 0 19 0 10 10 0 10 10 0 0 19 10 % R
% Ser: 0 55 0 10 0 0 0 37 0 46 0 19 10 0 10 % S
% Thr: 19 0 10 10 0 0 0 10 10 0 10 0 0 0 0 % T
% Val: 10 0 0 28 0 0 10 0 0 10 10 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 0 0 46 0 % W
% Tyr: 0 0 0 0 37 10 10 0 37 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _