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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APTX All Species: 16.67
Human Site: S182 Identified Species: 30.56
UniProt: Q7Z2E3 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z2E3 NP_060162.1 356 40740 S182 K E S L G H W S Q G L K I S M
Chimpanzee Pan troglodytes XP_001158355 356 40779 S182 K E S L G H W S Q G L K I S M
Rhesus Macaque Macaca mulatta XP_001090958 296 34012 M134 I S M Q D P K M Q V Y K D E Q
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q7TQC5 342 38704 S168 K E S L G H W S Q G L K M S M
Rat Rattus norvegicus Q8K4H4 329 37701 P165 L K I S M K D P K M Q V Y K D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506988 408 45957 S180 Q E S F G H W S Q G L K T S M
Chicken Gallus gallus P61798 316 36000 V154 S S M Q D P K V Q V Y K D E K
Frog Xenopus laevis Q7T287 347 39626 S173 V K S Q G H W S Q D L K V S M
Zebra Danio Brachydanio rerio P61799 324 36503 M162 A S M Q D P K M Q V Y K D D S
Tiger Blowfish Takifugu rubipres P61800 356 40172 N182 Q G S V G H W N L G L K A S M
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392143 194 22668 P31 L L V S M E D P R Y K V K E D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797394 169 19599
Poplar Tree Populus trichocarpa XP_002323598 718 79266 N249 S T A D F Q F N N E K A S D I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 78.6 N.A. N.A. 82 78.3 N.A. 52.4 48 57 54.7 55.6 N.A. 24.4 N.A. 26.9
Protein Similarity: 100 99.7 79.2 N.A. N.A. 87.3 83.1 N.A. 63.9 60.6 73.3 69 71.9 N.A. 35.9 N.A. 36.2
P-Site Identity: 100 100 13.3 N.A. N.A. 93.3 0 N.A. 80 13.3 66.6 13.3 60 N.A. 0 N.A. 0
P-Site Similarity: 100 100 13.3 N.A. N.A. 100 13.3 N.A. 86.6 13.3 80 13.3 80 N.A. 6.6 N.A. 0
Percent
Protein Identity: 23.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 33.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 0 0 0 0 0 0 0 8 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 24 0 16 0 0 8 0 0 24 16 16 % D
% Glu: 0 31 0 0 0 8 0 0 0 8 0 0 0 24 0 % E
% Phe: 0 0 0 8 8 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 0 0 47 0 0 0 0 39 0 0 0 0 0 % G
% His: 0 0 0 0 0 47 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 8 0 0 0 0 0 0 0 0 0 16 0 8 % I
% Lys: 24 16 0 0 0 8 24 0 8 0 16 70 8 8 8 % K
% Leu: 16 8 0 24 0 0 0 0 8 0 47 0 0 0 0 % L
% Met: 0 0 24 0 16 0 0 16 0 8 0 0 8 0 47 % M
% Asn: 0 0 0 0 0 0 0 16 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 24 0 16 0 0 0 0 0 0 0 % P
% Gln: 16 0 0 31 0 8 0 0 62 0 8 0 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % R
% Ser: 16 24 47 16 0 0 0 39 0 0 0 0 8 47 8 % S
% Thr: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % T
% Val: 8 0 8 8 0 0 0 8 0 24 0 16 8 0 0 % V
% Trp: 0 0 0 0 0 0 47 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 24 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _