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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CACNA2D4
All Species:
23.33
Human Site:
S523
Identified Species:
46.67
UniProt:
Q7Z3S7
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z3S7
NP_758952.4
1137
127966
S523
S
K
K
N
E
T
R
S
H
G
I
L
L
G
V
Chimpanzee
Pan troglodytes
XP_001152797
1143
128562
S529
S
K
K
N
E
T
R
S
H
G
I
L
L
G
V
Rhesus Macaque
Macaca mulatta
XP_001117901
1076
120805
S462
S
K
K
N
E
T
R
S
H
G
I
L
L
G
V
Dog
Lupus familis
XP_534930
1121
125577
S506
S
K
K
N
E
T
R
S
H
G
I
L
L
G
V
Cat
Felis silvestris
Mouse
Mus musculus
Q5RJF7
1116
125972
S502
S
K
K
N
E
T
R
S
H
G
I
L
L
G
V
Rat
Rattus norvegicus
Q8CFG5
1085
122186
G488
Q
N
E
T
R
S
K
G
I
L
L
G
V
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520798
808
90331
S256
I
V
V
D
V
S
G
S
M
K
G
L
Q
M
T
Chicken
Gallus gallus
XP_414338
1090
123764
N487
M
P
V
F
S
K
Q
N
E
T
R
S
K
G
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_696635
1094
123822
S475
S
K
K
E
E
T
L
S
H
G
I
L
L
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610902
1218
140030
R552
D
R
R
E
N
A
T
R
I
A
N
I
L
G
V
Honey Bee
Apis mellifera
XP_623849
1156
130746
K472
D
R
R
N
Y
T
V
K
T
A
N
L
L
G
I
Nematode Worm
Caenorhab. elegans
P34374
1249
144358
V557
T
V
S
Y
P
V
I
V
N
E
T
F
M
G
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
86.9
84.9
N.A.
82.7
57.4
N.A.
58.5
58.3
N.A.
61
N.A.
33
30.1
21.7
N.A.
Protein Similarity:
100
98.8
89
91.3
N.A.
89.2
75.1
N.A.
65.5
75.9
N.A.
77.1
N.A.
51.7
48.7
42.9
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
13.3
6.6
N.A.
86.6
N.A.
20
33.3
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
26.6
26.6
N.A.
86.6
N.A.
40
53.3
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
0
0
0
17
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
9
17
50
0
0
0
9
9
0
0
0
0
0
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
0
0
0
0
0
0
9
9
0
50
9
9
0
84
9
% G
% His:
0
0
0
0
0
0
0
0
50
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
0
0
9
0
17
0
50
9
0
0
17
% I
% Lys:
0
50
50
0
0
9
9
9
0
9
0
0
9
0
0
% K
% Leu:
0
0
0
0
0
0
9
0
0
9
9
67
67
0
0
% L
% Met:
9
0
0
0
0
0
0
0
9
0
0
0
9
9
0
% M
% Asn:
0
9
0
50
9
0
0
9
9
0
17
0
0
0
0
% N
% Pro:
0
9
0
0
9
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
9
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% Q
% Arg:
0
17
17
0
9
0
42
9
0
0
9
0
0
0
0
% R
% Ser:
50
0
9
0
9
17
0
59
0
0
0
9
0
0
0
% S
% Thr:
9
0
0
9
0
59
9
0
9
9
9
0
0
0
9
% T
% Val:
0
17
17
0
9
9
9
9
0
0
0
0
9
9
67
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _