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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CACNA2D4 All Species: 23.03
Human Site: T869 Identified Species: 46.06
UniProt: Q7Z3S7 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q7Z3S7 NP_758952.4 1137 127966 T869 Q R K F W A A T R Q C S T V D
Chimpanzee Pan troglodytes XP_001152797 1143 128562 T875 Q R K F W A A T R Q C S T V D
Rhesus Macaque Macaca mulatta XP_001117901 1076 120805 T808 Q R K F W A A T R Q C S T V D
Dog Lupus familis XP_534930 1121 125577 T852 Q R T F W A A T W Q C S T V E
Cat Felis silvestris
Mouse Mus musculus Q5RJF7 1116 125972 M848 Q R Q F W A A M Q Q C N A V E
Rat Rattus norvegicus Q8CFG5 1085 122186 S829 Q R K F W T A S R Q C A S L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520798 808 90331 G568 A M I N G E T G Y L A M D V K
Chicken Gallus gallus XP_414338 1090 123764 S834 Q R K F W T A S R Q C A S L D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_696635 1094 123822 A828 E K R F W S I A N Q C S G I E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610902 1218 140030 A921 G F Q F Q H S A L Y K L F H N
Honey Bee Apis mellifera XP_623849 1156 130746 N852 S L A S R F V N I T S T C S G
Nematode Worm Caenorhab. elegans P34374 1249 144358 Y935 G Q A F K A I Y L D K A V L G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 86.9 84.9 N.A. 82.7 57.4 N.A. 58.5 58.3 N.A. 61 N.A. 33 30.1 21.7 N.A.
Protein Similarity: 100 98.8 89 91.3 N.A. 89.2 75.1 N.A. 65.5 75.9 N.A. 77.1 N.A. 51.7 48.7 42.9 N.A.
P-Site Identity: 100 100 100 80 N.A. 60 66.6 N.A. 6.6 66.6 N.A. 33.3 N.A. 6.6 0 13.3 N.A.
P-Site Similarity: 100 100 100 86.6 N.A. 86.6 93.3 N.A. 6.6 93.3 N.A. 73.3 N.A. 26.6 6.6 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 17 0 0 50 59 17 0 0 9 25 9 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 67 0 9 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 9 0 0 9 0 42 % D
% Glu: 9 0 0 0 0 9 0 0 0 0 0 0 0 0 25 % E
% Phe: 0 9 0 84 0 9 0 0 0 0 0 0 9 0 0 % F
% Gly: 17 0 0 0 9 0 0 9 0 0 0 0 9 0 17 % G
% His: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 0 9 0 0 0 17 0 9 0 0 0 0 9 0 % I
% Lys: 0 9 42 0 9 0 0 0 0 0 17 0 0 0 9 % K
% Leu: 0 9 0 0 0 0 0 0 17 9 0 9 0 25 0 % L
% Met: 0 9 0 0 0 0 0 9 0 0 0 9 0 0 0 % M
% Asn: 0 0 0 9 0 0 0 9 9 0 0 9 0 0 9 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 59 9 17 0 9 0 0 0 9 67 0 0 0 0 0 % Q
% Arg: 0 59 9 0 9 0 0 0 42 0 0 0 0 0 0 % R
% Ser: 9 0 0 9 0 9 9 17 0 0 9 42 17 9 0 % S
% Thr: 0 0 9 0 0 17 9 34 0 9 0 9 34 0 0 % T
% Val: 0 0 0 0 0 0 9 0 0 0 0 0 9 50 0 % V
% Trp: 0 0 0 0 67 0 0 0 9 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 9 9 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _