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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIWIL3
All Species:
13.64
Human Site:
S416
Identified Species:
25
UniProt:
Q7Z3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z3Z3
NP_001008496.2
882
101089
S416
D
E
I
C
K
D
Y
S
I
V
K
E
L
A
K
Chimpanzee
Pan troglodytes
XP_528661
878
100916
S412
D
E
I
R
K
D
Y
S
I
M
K
E
L
A
K
Rhesus Macaque
Macaca mulatta
XP_001099093
882
101146
S416
D
E
I
R
K
D
Y
S
T
M
K
E
L
A
K
Dog
Lupus familis
XP_534638
861
98542
N401
D
K
M
R
N
D
F
N
V
M
K
D
L
A
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMB7
862
98556
N402
D
K
M
R
N
D
F
N
V
M
K
D
L
A
V
Rat
Rattus norvegicus
Q4G033
848
95953
T398
M
K
A
V
A
E
E
T
R
L
S
P
M
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509070
1180
134396
T720
D
K
M
R
S
D
F
T
V
M
K
D
L
A
V
Chicken
Gallus gallus
A6N7Y9
867
99268
M409
M
R
N
D
F
N
M
M
K
D
L
A
V
H
T
Frog
Xenopus laevis
Q6DCX2
862
97626
V397
S
F
N
T
D
P
F
V
R
E
F
G
I
M
V
Zebra Danio
Brachydanio rerio
Q8UVX0
858
97433
I399
K
M
R
A
D
F
N
I
M
K
D
L
A
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKM1
843
97159
K396
S
Y
T
R
M
N
P
K
Q
R
T
D
R
L
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999765
854
96704
K395
R
A
D
F
N
V
M
K
D
M
G
Q
H
T
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SJK3
997
111116
K482
Y
T
K
R
L
N
E
K
Q
V
T
A
L
L
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
95.1
50.2
N.A.
50
39.4
N.A.
38.9
48.1
21.4
45.5
N.A.
32.9
N.A.
N.A.
38.5
Protein Similarity:
100
99.3
96.9
67
N.A.
67
58.6
N.A.
52.5
66.7
41.2
63.2
N.A.
53.8
N.A.
N.A.
57.7
P-Site Identity:
100
86.6
80
33.3
N.A.
33.3
0
N.A.
33.3
0
0
0
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
93.3
86.6
80
N.A.
80
40
N.A.
80
13.3
13.3
13.3
N.A.
20
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
8
0
0
0
0
0
0
16
8
47
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
8
8
16
47
0
0
8
8
8
31
0
0
0
% D
% Glu:
0
24
0
0
0
8
16
0
0
8
0
24
0
0
0
% E
% Phe:
0
8
0
8
8
8
31
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
8
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
8
% H
% Ile:
0
0
24
0
0
0
0
8
16
0
0
0
8
0
0
% I
% Lys:
8
31
8
0
24
0
0
24
8
8
47
0
0
0
31
% K
% Leu:
0
0
0
0
8
0
0
0
0
8
8
8
54
16
0
% L
% Met:
16
8
24
0
8
0
16
8
8
47
0
0
8
8
0
% M
% Asn:
0
0
16
0
24
24
8
16
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
8
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
16
0
0
8
0
0
0
% Q
% Arg:
8
8
8
54
0
0
0
0
16
8
0
0
8
0
24
% R
% Ser:
16
0
0
0
8
0
0
24
0
0
8
0
0
8
0
% S
% Thr:
0
8
8
8
0
0
0
16
8
0
16
0
0
8
8
% T
% Val:
0
0
0
8
0
8
0
8
24
16
0
0
8
0
31
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
0
0
0
0
24
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _